Table I Up-regulated candidates in OSCC
GOaSwiss-ProtGene nameT/N ratiobCancer associationc (detection methodc) (Ref.)Possible regulation
ID_HUMANCode16N116T116T216N316T3MeanFreq.OSCCOther cancers
Cell proliferation
    1SYWCP23381WARS20.5013.5340.6025.5717.3823.525/5ISG-ISCP
    2BIGH3Q15582TGFBI21.482.982.313.603.896.855/5Colon (86, 87), pancreas (88)
    3K1C16P08779KRT1660.2522.400.4826.7722.6926.524/5(P, IHC) (15)
    4K2C6AP02538KRT6A39.4013.900.512.851.3211.603/5
    5FSCN1Q16658FSCN18.513.931.041.932.453.573/5(IHC, TMA) (89, 90)Esophagus (91, 92), colon (93), kidney (94), breast (95), lung (96), ovary (97)
    6ITA6P23229ITGA61.363.97ND3.012.542.723/4
    7IFM1P13164IFITM1NDND3.024.902.593.503/3ISG
    8K2C6EP48668KRT6C22.12NQ1.149.88NQ11.042/3Lung (98)
Cell organization and biogenesis
    9STAT1P42224STAT17.705.533.948.374.546.025/5Stomach (99)ISG-ISCP
    10TYPHP19971TYMP9.455.482.305.135.105.495/5(G, P, IHC) (100–102)Pancreas (103), breast (104), nasopharynx (105)ISG
    11FLNBO75369FLNB2.774.682.245.703.523.785/5ISCP
    12FLNAP21333FLNA4.533.502.172.322.082.925/5ISCP
    13P4HA1P13674P4HA1ND15.80ND9.3218.0614.393/3Breast (106), stomach (107)
    14LIMA1Q9UHB6LIMA1ND6.98ND3.102.714.263/3
    15LRC59Q96AG4LRRC593.002.44ND4.06ND3.173/3
Defense
    16UCRPP05161ISG1533.3816.4038.999.268.7121.355/5Bladder (82), breast (83)ISG
    17MX1P20591MX18.666.875.413.804.435.835/5ISG-ISCP
    18HLAGP17693HLA-GNQND3.075.356.344.923/3Stomach (108)
    19PGAM1P18669PGAM12.692.362.56NDND2.533/3
    20GBP1P32455GBP1NQNQNQ13.8820.3917.132/2ISG-ISCP
    21HB2GP01911HLA-DRB2NDNDND7.649.478.562/2
    22GBP2P32456GBP2ND8.37NQNQ4.166.272/2ISG
    232DRAP01903HLA-DRA2.64ND7.37NDND5.012/2
Cell communication
    24TENAP24821TNC31.4923.291.5714.71260.9266.404/5(IHC) (109, 110)
    25EPIPLP58107EPPK117.8239.401.234.332.7613.114/5ISCP
    26FIBBP02675FGB21.199.402.752.061.697.424/5
    27CKAP4Q07065CKAP45.743.181.442.732.183.054/5
    28LDHAP00338LDHA2.942.981.693.822.162.724/5ISCP
    29FIBAP02671FGA13.137.120.471.322.034.823/5
    30LAMB3Q13751LAMB319.9415.55NDNDND17.742/2
    31ANXA3P12429ANXA319.666.39NDNDNQ13.022/2ISCP
Regulation of biological process
    32K1C17Q04695KRT17170.9014.563.6472.458.2353.965/5Basal cell (111)
    33SERPHP50454SERPINH113.739.912.9310.728.349.135/5(G, IHC) (112)Pancreas (113, 114)ISCP
    34PMLP29590PML8.503.07ND2.87ND4.813/5Thyroid (115)ISG-ISCP
    35GRP78P11021HSPA53.832.871.303.141.932.613/5Stomach (116), esophagus (117)
    36SODMP04179SOD20.86ND9.622.932.423.963/4(P, IHC) (22)Head and neck (118), esophagus (119)
Cell motility
    37S10A2P29034S100A24.493.431.113.164.133.264/5Pancreas (120), esophagus (121), bladder (122)
    38FINCP02751FN123.456.40ND5.863.819.884/4(G, IHC) (123)Ovary (124), breast (125), head and neck (126), larynx (127)
    39ITB4P16144ITGB45.543.192.85ND2.363.484/4
    40ACTN1P12814ACTN18.744.131.434.271.203.953/5ISCP
    41TPM4P67936TPM47.94NQNQ4.523.545.343/3
    42TSP1P07996THBS1121.6147.79NDNDND84.702/2(IHC) (128, 129)Head and neck (130), cervix (131), prostate (132), colon (133), stomach (134)
    43LAMC2Q13753LAMC24.6923.03NDNDND13.862/2
Development
    44NDRG1Q92597NDRG15.845.500.523.003.943.764/5(G, WB, IHC) (135)Liver (136, 137), colon (138)
    45COCA1Q99715COL12A131.455.09ND16.692.1613.854/4
    46APOL2Q9BQE5APOL2ND8.384.6417.352.478.214/4
    47K1C14P02533KRT1418.859.900.511.775.727.353/5HNSCC (139)
    48CAH2P00918CA2NDND3.27NQ7.705.492/2
Metabolism
    49OXRPQ9Y4L1HYOU13.982.71ND2.532.873.024/4
    50AMPLP28838LAP3ND1.456.544.063.503.893/4ISG-ISCP
Transporter
    51GTR1P11166SLC2A14.314.130.702.561.992.743/5
    52TAP1Q03518TAP1ND3.65ND2.902.743.103/3
Unknown
    53EFHD2Q96C19EFHD22.95NDND2.182.552.563/3
  • a Proteins were classified using GO criteria according to biological function.

  • b Fold changes in target protein expression in tumor (T) and non-tumor (N) cells. Freq., frequency of target up- or down-regulated proteins in detectable samples; ND, not detected; NQ, detected but not quantified.

  • c Target proteins that were dysregulated in tumor cells as determined using genomics (G), proteomics (P), IHC, and Western blot (WB) approaches.