Table II Down-regulated candidates in OSCC
GOaSwiss-ProtGene nameT/N ratiobCancer associationc (detection methodc) (Ref.)Possible regulation
ID_HUMANCode16N116T116T216N316T3MeanFreq.OSCCOther cancers
Cell organization and biogenesis
    1K1C19P08727KRT190.080.010.020.070.080.055/5
    2TSPOP30536TSPO0.550.41ND0.240.310.383/4
Regulation of biological process
    3HS70LP34931HSPA1L0.440.300.540.220.240.354/5
    4HSP71P08107HSPA1A0.420.300.620.200.240.364/5ISCP
    5KCRUP12532CKMT1A0.380.17ND0.350.460.344/4
    6AOFAP21397MAOAND0.08ND0.080.170.113/3
Development
    7K1C13P13646KRT130.070.020.030.030.120.055/5(P, IHC) (17)
    8K1C15P19012KRT150.080.030.070.010.120.065/5Head and neck (139)
    9PEPLO60437PPL0.250.190.440.250.160.265/5Head and neck (140)
    10EVPLQ92817EVPL0.310.240.390.250.190.285/5
    11SERAO43175PHGDHND0.07ND0.050.140.093/3ISCP
    12PRELPP51888PRELPND0.020.20NQND0.112/2
Metabolism
    13K2C4P19013KRT40.040.05NQ0.030.130.064/4(P, IHC) (70)Head and neck (15, 139)
    14AL3A1P30838ALDH3A10.100.09ND0.200.120.134/4
    156PGDP52209PGD0.160.160.460.50ND0.323/4ISCP
    16AL4A1P30038ALDH4A10.28NDND0.220.190.233/3
    17AL3A2P51648ALDH3A20.190.15ND0.35NQ0.233/3
    18EST2O00748CES20.39ND0.160.16ND0.243/3
    19TTL12Q14166TTLL120.350.32NDND0.330.343/3
    20ADH7P40394ADH70.0050.02NDNDND0.012/2
    21AL1A1P00352ALDH1A10.0020.06NDNDND0.032/2
    22ALDH2P05091ALDH20.120.11NDNDND0.112/2
    23AL9A1P49189ALDH9A10.110.23NDNDND0.172/2
Unknown
    24S10AGQ96FQ6S100A160.400.260.430.430.420.395/5
    25MGST2Q99735MGST20.23NDND0.270.240.243/3
    26TACD2P09758TACSTD20.360.28NDND0.250.303/3
    27S10AEQ9HCY8S100A140.300.23ND0.49ND0.343/3Bladder (141), esophagus (142)
  • a Proteins were classified using GO criteria according to biological function.

  • b Fold changes in target protein expression in tumor (T) and non-tumor (N) cells. Freq., frequency of target up- or down-regulated proteins in detectable samples; ND, not detected; NQ, detected but not quantified.

  • c Target proteins that were dysregulated in tumor cells as determined using proteomics (P) and IHC approaches.