Table I Clinical characteristic of training set and validation set cohorts and controls groups

IF/TA, IF/TA with no other etiology; GFR, GFR from serum creatinine estimate by Modification of Diet in Renal Disease (MDRD) Study (49) equation (eGFR = 186 × (SCr)−1.154 × (age)−0.203 × (0.742 if female) × (1.21 if African American)).

CAD (mean ± S.D.)Control (mean ± S.D.)
IF/TA groupCAAR groupStable renal transplant recipientsHealthy controls
Training set
    Sample number (n)81059
    Age (yr)51 ± 10.6947.22 ± 17.07a36.2 ± 843 ± 10
    Creatinine (mg/dl)3.2 ± 1.682.98 ± 1.64a1.08 ± 0.30.91 ± 0.3
    GFR (ml/min/1.73 m2)28.88 ± 17.6533.44 ± 12.05a82.22 ± 4110 ± 10
    Proteinuria (g/24 h)2.67 ± 2.903.11 ± 3.33a0.20 ± 0.050.11 ± 0.02
Validation set
    Sample number (n)101199
    Age (yr)53.7 ± 17.854.09 ± 12.08a50.1 ± 1341 ± 9.5
    Creatinine (mg/dl)2.49 ± 0.742.05 ± 0.37a0.96 ± 0.10.78 ± 0.11
    GFR (ml/min/1.73 m2)28.34 ± 8.7631.6 ± 9.5a83.9 ± 14.5103 ± 12
    Proteinuria (g/24 h)1.37 ± 1.441.84 ± 2.47a0.17 ± 0.100.11 ± 0.51
  • a t test not significant between IF/TA versus CAAR groups.