Table III Differentially expressed proteins involved in glucose metabolism in gastric cardia cancer compared with normal tissues

NA, not applicable; ID, identity; M, Modest; P, Poor.

Spot no.Protein IDAccession no.Theoretical molecular mass (kDa)/pIExperimental mass (kDa)/pIPeptides matchedSequence coverageTotal scoreDifferential ratioFunction
Tumor differentiationLymph node metastasis
MPN0N1
%
G1Fructose-bisphosphate aldolase (EC 4.1.2.13)AAA5169739.4/8.232/8.213.86132.16.64.4Glycolysis
G2Glyceraldehyde-3- phosphate dehydrogenase (EC 1.2.1.12)AAA5249636.05/8.7333/8.414.2972.15.83.84.8Glycolysis
G32-phospho-d-glycerate hydrolyase (EC 4.2.1.11)AAA5238747.2/7.4642/6.527.11303.92.91.13.4Glycolysis
G4Pyruvate kinase isozymes M1/M2 (EC 2.7.1.40)AAA3667258/7.758/8.524.5126−2.6−3−11.8−5.9Glycolysis
G5Pyruvate kinase isozymes M1/M2 (EC 2.7.1.40)AAA3667258/7.736/6.037.722441.8NANAGlycolysis
G6l-Lactate dehydrogenase B (EC 1.1.1.27)NP_00229136.6/5.937/5.5415.8247−3−2−1.4−2.1Anaerobic respiration
G7Pyruvate dehydrogenase (lipoamide) (EC 1.2.4.1)NP_00091639.2/6.638/5.028.9116−0.9−3NANAKrebs cycle
G8Aconitate hydratase (EC 4.2.1.3)CAI1793185.4/7.685/8.557.1289NANA−9.7−16.9Krebs cycle
G9Aconitate hydratase (EC 4.2.1.3)CAI1793185.4/7.685/8.2711.5470NANA−6.4−6.8Krebs cycle
G10Isocitrate dehydrogenase (EC 1.1.1.42)NP_00588746.6/7.046/7.0511.82191−1.5NANAKrebs cycle
G11Fumarate hydratase (EC 4.2.1.2)CAI1390854.6/9.250/9.037.8239NANA−2.8−2.8Krebs cycle
G12Malate dehydrogenase (EC 1.1.1.37)CAG3368636.4/7.436/7.238.7106−10.4−3.9NANAKrebs cycle
G13Ubiquinol-cytochrome-c reductase (EC 1.10.2.2) core protein IEAW6489852.6/6.452.0/6.036144−2.5−2.3NANAOxidative phosphorylation