Table II Urinary proteins showing a median change of over 2 fold in stone-formers
IDaStone formers to Control ratiobEntrez Gene NameRepresentative PLGS scoreFraction number observedcSeq cov %# of distinct peptidesSubcellular locationFunction
Q86V850.16G protein-coupled receptor 180141.375, control9.53unknownReceptor
Q86SR00.29Ly6/neurotoxin 1230.1112, control46.46Plasma MembraneIon channel inhibitor
P196520.33orosomucoid 2160.51, control32.86Extracellular SpaceAcute phase plasma protein
P147800.35matrix metallopeptidase 9688.543, control36.218Extracellular SpaceProtease
Q9Y6460.365plasma glutamate carboxypeptidase326.227, control25.68Extracellular SpaceProtease
Q9NQ840.37RAIG-3187.343, control19.76Plasma MembraneReceptor
P082460.4elastase, neutrophil expressed139.69, control27.34Extracellular SpaceProtease
P565370.41eukaryotic translation initiation factor 6309.15, control46.18Cytoplasmtranslation regulator
P054510.41Lithostathin1127, control43.46Extracellular Spacegrowth factor
P258150.43S100 calcium binding protein P324.95, control35.83CytoplasmCalcium/Magnesium ion binding
P079110.44Uromodulin2778.143, control55.631Extracellular SpaceCalcium ion binding
P310250.44lipocalin 1 (tear prealbumin)180.15, control30.74Extracellular SpaceProtease inhibitor
P110210.45HSP70–5313.516, control24.811CytoplasmChaperone
Q8WVV50.46butyrophilin, subfamily 2, member A2178.111, control13.43unknownUnknown
P027630.475orosomucoid 1388.881, control42.35Extracellular SpaceAcute phase plasma protein
Q9H3G50.49carboxypeptidase, vitellogenic-like477.356, control208unknownCarboxypeptidase
P122730.495prolactin-induced protein569.986, control44.56Extracellular SpaceUnknown
P280662.01PSC5105.45, stone36.96CytoplasmPeptidase
P047922.015heat shock 27kDa protein 1107.26, stone213CytoplasmChaperone
P137272.12proteoglycan 2, bone marrow821, stone28.86Extracellular SpaceImmune response
P027502.14leucine-rich alpha-2-glycoprotein 1928.83, stone39.813Extracellular SpaceUnknown
P007392.16haptoglobin-related protein659.48, stone39.410Extracellular SpacePeptidase
P081852.16serpin peptidase inhibitor292.65, stone26.28Extracellular SpaceProtease inhibitor
P077372.18profilin 1218.66, stone58.65CytoplasmActin binding
Q96S962.335phosphatidylethanolamine-binding protein 4166.211, stone12.83CytoplasmLipid binding
P007382.59Haptoglobin1582.48, stone48.318Extracellular Spaceproteolysis & iron homeostasis
P698912.64hemoglobin, gamma A142.32, stone36.14Cytoplasmoxygen transport
P698923.06hemoglobin, gamma G1402, stone25.23Cytoplasmoxygen transport
P004503.13ceruloplasmin (ferroxidase)1846.810, stone54.239Extracellular Spacemetal ion binding
P004413.42superoxide dismutase 1278.68, stone34.43Cytoplasmmetal ion binding
P026753.47fibrinogen beta chain318.98, stone37.716Extracellular Spaceclotting
P026793.53fibrinogen gamma chain265.52, stone30.79Extracellular Spaceclotting
Q9BVK63.82transmembrane emp24 protein transport domain containing 974.77, stone25.74CytoplasmUnknown
P010235.87alpha-2-macroglobulin827.2712, stone33.631Extracellular SpaceProtease inhibitor/cytokine transporter
  • a Accession number from the SwissProt Database.

  • b Median of quantitative data values obtained from two independent experiments.

  • c Fraction number with a representative PLGS score for this protein.