Table II Descriptives of the IgG glycome in three populations. IgG glycans were analyzed for individuals from the Croatian Adriatic islands Vis (n = 915), Korčula (n = 906) and Orkney (n = 477). Median values, interquartile ranges (IQR), and minimal and maximal values are shown. Calculations and descriptions of derived glycosylation traits are explained in the Experimental Procedures section. An extended list of derived glycan features is available in supplementary Table S3
IgG glycanPopulation: VisPopulation: KorčulaPopulation: Orkney
Median (IQR)Min-MaxMedian (IQR)Min-MaxMedian (IQR)Min-Max
GP10.16 (0.19)0.02–2.380.15 (0.12)0.03–1.020.16 (0.1)0.04–1.24
GP20.74 (0.55)0.11–5.20.72 (0.57)0.14–9.390.71 (0.53)0.17–4.59
GP420.39 (8.61)6.56–42.3720.05 (8.54)6.07–41.3420.14 (8.17)8.08–49.47
GP50.31 (0.13)0.09–0.970.29 (0.14)0.12–0.970.27 (0.09)0.13–0.84
GP65.24 (2.15)1.93–12.865.5 (2.2)1.79–11.094.82 (2.11)1.95–10.65
GP70.67 (0.52)0.14–4.010.68 (0.46)0.15–4.060.48 (0.31)0.12–1.72
GP816.42 (2.61)9.84–23.716.2 (2.53)8.93–23.5618.08 (2.21)11.89–25.4
GP97.9 (1.57)4.27–11.87.95 (1.69)4.6–12.198.98 (1.59)5.01–12.5
GP104.59 (1.3)2.48–10.24.6 (1.22)2.59–8.194.48 (1.11)2.64–13.37
GP110.75 (0.2)0.33–2.920.76 (0.2)0.4–1.820.77 (0.19)0.44–1.41
GP120.96 (0.64)0.26–6.140.98 (0.69)0.23–3.910.8 (0.5)0.21–3.87
GP130.25 (0.16)0.08–1.590.22 (0.07)0.1–1.010.24 (0.07)0.13–0.58
GP1411.02 (5.06)3.39–22.9710.77 (4.83)3.5–24.8112.26 (5.07)3.66–23.91
GP151.41 (0.48)0.71–2.891.51 (0.46)0.68–2.811.64 (0.45)0.77–2.83
GP163.13 (0.68)1.99–5.113.21 (0.61)1.82–5.223.21 (0.61)1.69–5.25
GP172.61 (1.85)1–13.612.43 (1.67)0.94–10.451.58 (0.53)0.92–7.73
GP188.58 (3.65)3.96–18.028.83 (3.52)3.58–26.029.33 (3.67)3.45–18.92
GP192.45 (0.7)1.16–9.032.41 (0.63)1.15–5.12.38 (0.48)1.3–4.54
GP200.43 (0.43)0.07–3.250.62 (0.49)0.11–3.460.49 (0.22)0.25–2.56
GP213.41 (2.38)1.03–23.823.2 (2.83)0.98–24.61.56 (0.68)0.67–6.01
GP220.36 (0.21)0.06–1.330.31 (0.13)0.08–1.460.29 (0.12)0.06–0.88
GP231.98 (0.79)0.71–13.732.27 (0.83)0.9–4.672.3 (0.89)0.88–4.62
GP242.7 (0.79)1.02–7.662.72 (0.78)0.67–5.842.66 (0.71)0.97–8.86
FGS/(FG+FGS)28.15 (4.52)17.59–47.4529.5 (4.54)19.02–42.827.32 (4.09)19.63–37.27
FBGS/(FBG+FBGS)43.14 (8.86)14.07–74.6743.05 (7.84)21.95–60.7241.96 (7.16)12.06–66.91
FGS/(F+FG+FGS)19.71 (6.03)9.67–42.3420.82 (5.82)9.63–39.6219.99 (5.39)9.14–32.28
FBGS/(FB+FBG+FBGS)29.91 (7.99)10.16–65.4529.38 (7.64)14.17–48.8329.70 (7.36)10.37–51.19
FG1S1/(FG1+FG1S1)11.49 (2.59)7.38–22.1311.79 (2.33)7.21–22.0510.67 (2.02)5.99–15.84
FG2S1/(FG2+FG2S1+FG2S2)39.99 (3.28)32.05–49.4540.72 (3.22)33.24–50.0739.16 (3.26)25.21–48.48
FG2S2/(FG2+FG2S1+FG2S2)8.99 (3.3)3.61–33.2110.08 (3.44)2.18–30.649.45 (2.79)4.18–20.31
FBG2S1/(FBG2+FBG2S1+FBG2S2)37.2 (4.73)26.27–49.3436.2 (4.66)25.86–46.4935.92 (4)26.32–44.75
FBG2S2/(FBG2+FBG2S1+FBG2S2)41.09 (5.92)23.09–59.5840.73 (5.77)15.88–54.2539.48 (4.59)18.91–62.28
FBS1/(FS1+FBS1)0.17 (0.05)0.08–0.520.17 (0.05)0.04–0.360.16 (0.05)0.07–0.31
FBS2/(FS2+FBS2)0.58 (0.08)0.36–0.750.55 (0.08)0.37–0.780.54 (0.08)0.32–0.78
G0n37.09 (12.75)14.69–69.5737.22 (11.66)13.84–62.8234.62 (11.46)16.17–69.42
G1n42.6 (4.54)24.18–50.9642.73 (4.38)29.59–49.2644.45 (3.78)24.73–60.27
G2n19.17 (8.83)5.93–43.7618.88 (8.24)7.05–47.0920 (8.47)5.64–40.27
Fn total95.77 (2.32)84.19–98.6495.76 (2.37)80.7–98.6496.52 (1.8)88.16–98.67
FG0n total/G0n97.11 (1.95)81.33–99.5997.26 (2.09)77.55–99.5297.15 (1.89)86.42–99.41
FG1n total/G1n97.78 (1.67)87.05–99.5797.76 (1.57)86.77–99.5498.52 (0.91)94.55–99.6
FG2n total /G2n91.03 (5.05)72.7–97.3590.88 (4.32)73.66–98.0892.95 (3.37)80.66–97.51
Fn78.3 (4.62)63.83–87.4877.99 (4.72)60.95–86.5280.44 (4.05)67.55–88.92
FG0n/G0n77.02 (5.22)49.91–86.5576.18 (5.93)53.13–86.5478.3 (5.24)59.25–88.33
FG1n/G1n79.5 (4.5)66.38–87.6379.68 (4.46)67.99–87.6982.28 (4.1)68.72–90.2
FG2n/G2n80.42 (5.74)57.71–90.279.48 (5.58)60.13–89.5781.59 (5.28)63.28–90.49
FBn16.92 (3.45)10.87–25.917.27 (3.61)10.49–26.4315.74 (3.37)9–26.36
FBG0n/G0n19.85 (4.57)12.16–33.220.64 (4.7)11.66–36.8318.74 (4.14)10.51–32.08
FBG1n/G1n17.78 (3.91)11.1–28.4217.74 (4)10.73–28.4616.17 (4.07)8.85–30.76
FBG2n/G2n10.27 (2.39)6.36–30.9211.13 (3.06)5.78–24.3310.95 (3.06)5.72–20.94
FBn/Fn total17.76 (3.72)11.05–27.6418.18 (3.94)10.85–27.8116.35 (3.51)9.23–26.91