Table III Effect of inhibitors on the cleavage of synthetic peptide precursors by proteasome 20S
ActivityNo inhibitorMG-132Epoxomicin
31-merN. of Cleavages% ContributionaN. of Cleavages% ContributionaN. of Cleavages% Contributiona
Tryptic315.428.3311.6
Chymotryptic1365.11170.3970.1
Caspase21.220.900
Other1118.3720.5718.4
Total291002310020100
30-merN. of Cleavages% ContributionbN. of Cleavages% ContributionbN. of Cleavages% Contributionb
Tryptic427.6417.3312.7
Chymotryptic825.4935.2637.5
Caspase321.1212.1212.5
Other725.9835.4737.2
Total221002310018100
  • a Added values from Table VIS.

  • b Added values from Table VIIS.