Table I Mean intensity of the monoisotopic (M+H+) ion peaks of inhibitor-sensitive and resistant peptides. This analysis was performed for the peptides in Figure 4
MG-132Epoxomicin
14N15N15N+Inh.14N15N15N+Inh.
Sensitive (n = 31)13461110927026 (63%)c300124891644 (66%)c
Resistant (n = 5)28182364a1657 (70%)c551356b176 (49%)c
Ratio4.84.74.25.47.09.3
  • a Range: 537 to 5030. As many as 20 inhibitor-sensitive peptides (64.5%) had higher intensity.

  • b Range: 56 to 602. As many as 17 inhibitor-sensitive peptides (54.8%) had higher intensity.

  • c Percent values are relative to peptides labeled in the absence of inhibitor (15N).