Table II Proteins significantly up- or down-regulated in AS compared to controls. Individual sera were IgG depleted and albumin was biochemically removed. Proteins were digested and analysed by mass spectrometry. We identified 22 proteins which were significantly regulated between AS and control using LC-Progenesis software (p < 0.05 for significance of regulation)
±log2(AS/CTRL)p valueAccession [IPI]GeneProteinExpected level in acute phase
2.2390.001IPI00022389CRPCRP Isoform 1 of C-reactive proteinup[52]
0.7990.005IPI00022395C9C9 Complement component C9up[52]
0.6530.014IPI00006543CFHR5CFHR5 Complement factor H-related 5up[54]
0.4650.016IPI00022463TFTF Serotransferrindown[52]
0.4190.014IPI00019591CFBCFB cDNAFLI55673, highly similar to Complement factor Bup[52]
0.4060.014IPI00022391APCSAPCS Serum amyloid P-componentup[40]
0.4050.035IPI00550991SERPINA3SERPINA3 cDNAFLI35730fisup[52]
−0.3100.047IPI00026314GSNGSN Isoform 1 of Gelsolindown[54]
−0.3710.014IPI00218732PON1PON1 Serum paraoxonase/arylesterase 1down[55]
−0.3740.041IPI00305461ITIH2ITIH2 Inter-alpha (Globulin) inhibitor H2, isoform CRA_aup[52]
−0.3760.016IPI00027482SERPINA6SERPINA6 Corticosteroid-binding globulindown[56]
−0.3940.035IPI00292530ITIH1ITIH1 Inter-alpha-trypsin inhibitor heavy chain H1up[52]
−0.4410.036IPI00022229APOBAPOB Apolipoprotein B-100-
−0.4830.015IPI00022431AHSGAHSG cDNA FLI55606, highly similar to Alpha-2-HS-glycoproteindown[58]
−0.5240.035IPI00020996IGFALSIGFALS Insulin-like growth factor-binding protein complex acid labile subunit-
−0.5310.008IPI00032179SERPINC1SERPINC1 Antithrombin-IIIdown[57]
−0.5310.010IPI00296099THBS1THBS1 Thrombospondin-1-
−0.6720.014IPI00016381RAB27ARAB27A Isoform Long of Ras-related protein Rab-27A-
−0.6770.014IPI00795528C21orf59C21orf59 Protein-
−0.6770.015IPI00022432TTRTTR Transthyretindown[52]
−0.7670.014IPI00301689PPFIBP2PPFIBP2 Liprin-beta-2-
−0.8210.001IPI00328609SERPINA4SERPINA4 Kallistatindown[59]