Table II Seventy-five candidates list. Proteins were classified using protein name in turn. *manual check
CandidateaSwiss Prot/UniprotGe-LC (E1)2D-LC (E2)2D-LC (E3)FreqdSecretory pathway predictioneThyroid hormone association (Ref.)
AccessionProtein namePeptidebT3/Tdc ratioPeptidebT3/Tdc ratioPeptidebT3/Tdc ratioSignalPSecretomePTMHMM
UpP02760AMBP114.16142.84151.322/310.769NoNo
UpP01008ANT362.24152.55121.402/30.9870.645NoYes (56)
UpQ06481APLP242.69101.8794.392/310.507YesNo
UpP02652APOA222.21102.11101.822/310.849NoYes (44)
UpP06727APOA4133.27123.27131.502/310.419NoYes (45)
UpQ6Q788APOA5412.9463.8376.023/310.673NoYes (46)
UpP02654APOC1416.43412.512/210.945NoNo
UpP02655APOC233.4932.132/210.964NoYes (47)
UpP02649APOE154.99165.18163.283/310.88NoYes (48)
UpP00736C1R32.2472.1973.103/30.9980.697NoNo
UpP09871C1S112.9892.70102.763/310.73NoNo
UpP12830CADH123.6744.7641.712/30.9990.179YesYes (49)
UpO15467CCL1633.7427.252/20.9990.921NoNo
UpP08571CD14342.20834.84951.473/310.674NoNo
UpP11597CEIP24.25710.52714.003/30.9990.73NoYes (50)
UpP36222CH3L173.5973.40102.183/30.9980.645NoNo
UpQ9BWS9CHID122.4592.62104.583/310.733NoNo
UpP01024CO3712.27892.29811.992/310.618NoYes (13)
UpP39060COIA187.601012.972/20.9980.166NoYes (51)
UpQ9NZV1CRIM154.0043.0842.223/30.9950.521YesNo
UpQ9H2A7CXL1623.5232.592/20.9410.179YesNo
UpQ9UBS4DJB11511.09810.46821.263/30.9820.707YesNo
UpQ13217DNJC332.15211.982/20.8890.38NoNo
UpQ9Y6C2EMIL183.12124.762/210.239NoNo
UpQ13822ENPP2104.83244.82234.363/30.890.488YesYes (52)
UpP62495ERF141.7352.0037.142/300.444NoNo
UpP02671FIBA102.21266.56151.852/30.9990.397NoYes (53)
UpP02675FIBB62.67243.09121.282/30.9990.534NoYes (53)
UpP02679FIBG182.48192.85182.183/30.9320.696YesYes (13)
UpP02751FINC392.23622.92656.913/30.9970.369NoYes (13)
UpO95633FSTL323.7832.532/20.9950.9NoYes (54)
UpP09958FURIN57.6166.362/20.9820.388YesYes (16)
UpQ99988GDFI5712.371612.441621.123/30.9960.882NoNo
UpP06396GELS143.11133.052/210.553NoNo
UpP35052GPC153.4653.922/210.33NoNo
UpQ16270IBP72551.6554.982/30.9980.536NoNo
UpP30740ILEU52.2782.1741.192/30.0150.516NoNo
UpP05154IPSP91.91106.3162.003/310.838NoNo
UpP19823ITIH2232.22452.29394.033/310.509NoNo
UpP01042KNG134.0532.872/20.9960.489NoNo
UpP55268LAMB232.3642.7261.682/30.8770.261NoNo
UpP01130LDLR33.3193.2481.922/30.9990.475YesYes (55)
UpP48740MASP149.3983.4382.183/310.705NoNo
UpQ86UD1OAF43.7834.582/210.938NoNo
UpP05121PAI174.66194.53164.713/30.9990.644NoYes (59)
UpQ15084PDIA622.1391.8274.062/30.9990.711NoNo
UpP20142PEPC23.9722.072/20.9990.866NoNo
UpQ96NZ9PRAP154.8484.202/210.822NoNo
UpP10586PTPRF53.2773.73143.433/30.9980.419YesNo
UpP31431SDC4213.2046.7637.613/310.557YesNo
UpQ13214SEM3B72.42103.432/210.343YesNo
UpQ13275SEM3F33.1932.962/210.5NoNo
UpO75326SEM7A55.2085.7062.663/30.9990.484NoNo
UpP04278SHBG53.4862.062/210.708NoNo
UpP50453SPB933.1443.2921.912/30.0160.559NoNo
UpQ9BUD6SPON2210.47211.032/20.9990.766NoYes (37)
UpQ92563TICN279.33164.99187.223/310.232NoNo
UpP16035TIMP243.5854.2223.503/310.854NoNo
UpQ8WUA8TSK214.4825.32325.893/310.724NoNo
UpP02774VTDB23.42103.1050.592/310.434NoNo
UpQ6PCB0VWA163.0732.752/210.517NoYes (57)
*UpQ03405UPAR27.801/10.737NoNo
*UpQ9GZN4BSSP4333.251/10.9890.744NoNo
DownP19022CADH260.4090.3770.562/30.9990.203YesNo
DownP10909CLUS80.48100.58100.52/310.826NoYes (13)
DownP15924DESP80.0340.531.712/300.183NoNo
DownO94907DKK120.2060.312/20.9970.952NoNo
DownP02794FRIH40.4930.382/200.621NoYes (58)
DownP38159HNRPG30.3240.4133.532/300.276NoNo
DownQ86YZ3HORN70.0330.01325.12/30.0190.087NoNo
DownQ8WUJ3K119980.14180.18120.163/30.9930.42NoNo
DownP14923PLAK60.1460.42/200.475NoNo
DownP06737PYGL50.39100.5100.722/300.381NoNo
DownO15240VGF30.4230.272/210.315NoNo
*No-changeQ16658FSCN140.9540.9530.873/30.0010.385NoNo
  • a Up-regulated, down-regulated and non-changed by T3.

  • b Peptide, the number of identified peptides.

  • c Fold change in target protein expression in T3 treatment (T3) or not (Td) cells.

  • d Freq, frequency of target up, down-regulated and non-changed proteins in detectable samples.

  • e Proteins predicted secretory pathway using singalP, secretomeP and TMHMM software.