Table VII Differentially expressed proteins with signal sequence or transmembrane (TM) domains and their detectability in normal cerebrospinal fluid (CSF) or plasma

The protein list was extracted from supplemental Table IA after comparison with data from Refs. 21 and 22.

Gene symbolProtein namePeptidesFoldSignal/TMCSFPlasma
A1BGα1B-Glycoprotein precursor33.2Signal++
A2Mα2-Macroglobulin precursor172.2Signal++
ALBAlbumin preproprotein363.7Signal++
APOA1Apolipoprotein A-I preproprotein113.1Signal++
APOA2Apolipoprotein A-II preproprotein22.3Signal++
APOC1Apolipoprotein C-I precursor32.2Signal++
APOC3Apolipoprotein C-III precursor22.3Signal++
ARHGDIBRho GDP dissociation inhibitor β23.5TM+
ATP1A3Na+/K+-ATPase α3 subunit420.4TM+
B2Mβ2-microglobulin precursor25.8Signal++
BCANBrevican isoform 150.4TM++
C3Complement component 3 precursor192.4Signal++
C4BComplement component 4B preproprotein102.3Signal+
C9Complement component 9 precursor32.2TM++
CALRCalreticulin precursor132.0Signal++
CALUCalumenin isoform a precursor92.8Signal+
CANXCalnexin precursor163.2Signal+
CD163CD163 antigen isoform b53.8Signal++
CD44CD44 antigen isoform 4 precursor64.4Signal++
CHI3L1Chitinase 3-like 1 precursor314.7Signal++
CLUClusterin isoform 292.2Signal++
CNTNAP2Cell recognition molecule Caspr2 precursor30.5TM+
CPCeruloplasmin precursor124.1Signal++
EGFREpidermal growth factor receptor isoform b precursor33.3Signal++
F2Coagulation factor II preproprotein52.3Signal++
FCGR3AFc fragment of IgG, low affinity IIIa, receptor (CD16a) isoform d precursor25.0TM+
FGBFibrinogen, β chain preproprotein32.0TM++
FLNAFilamin A, α isoform 1312.9TM++
GALNT2Polypeptide N-acetylgalactosaminyltransferase 223.1TM++
GANABNeutral α-glucosidase AB isoform 2152.2Signal+
GLUD1Glutamate dehydrogenase 1 precursor140.5Signal+
GOLIM4Golgi integral membrane protein 445.6Signal+
GOT2Aspartate aminotransferase 2 precursor50.5Signal++
HLA-AMajor histocompatibility complex, class I, A precursor53.0Signal++
HLA-CMajor histocompatibility complex, class I, C precursor63.9Signal+
HLA-DRAMajor histocompatibility complex, class II, DR α precursor64.4TM+
HPHaptoglobin isoform 1 preproprotein93.4Signal+
HSP90B1Heat shock protein 90-kDa β, member 1 precursor292.4TM++
ICAM1Intercellular adhesion molecule 1 precursor43.4Signal+
ITGA5Integrin α5 precursor22.2TM+
ITGB1Integrin β1 isoform 1A precursor92.6TM++
L1CAML1 cell adhesion molecule isoform 3 precursor160.5TM+
LAMP2Lysosomal-associated membrane protein 2 isoform A precursor32.2TM++
LMAN2Lectin, mannose-binding 2 precursor62.1TM++
MLECMalectin precursor52.4TM+
MPOMyeloperoxidase133.3Signal+
MRC2Mannose receptor, C type 227.6TM++
MSNMoesin193.9TM++
MYH9Myosin, heavy polypeptide 9, nonmuscle702.5TM+
NCAM1Neural cell adhesion molecule 1 isoform 2200.4TM++
NEGR1Neuronal growth regulator 1 precursor50.5Signal++
OPCMLOpioid binding protein/cell adhesion molecule-like isoform b preproprotein30.5Signal++
ORM1Orosomucoid 1 precursor64.9Signal++
PDIA3Protein-disulfide isomerase A3 precursor192.3Signal+
PDIA6Protein-disulfide isomerase A6 precursor92.6Signal+
PLGPlasminogen310.2Signal++
PODXLPodocalyxin-like isoform 2 precursor33.3Signal+
PTPRCProtein-tyrosine phosphatase, receptor type, C isoform 2 precursor122.6TM+
PTPRZ1Protein-tyrosine phosphatase, receptor-type, ζ1 precursor80.5TM+
RTN4Reticulon 4 isoform C40.2Signal+
RTN4Reticulon 4 isoform B63.2TM+
S100A8S100 calcium-binding protein A855.6TM++
SERPINA3Serpin peptidase inhibitor, clade A, member 3 precursor23.0Signal++
SLC2A1Solute carrier family 2 (facilitated glucose transporter), member 152.2TM+
SLC4A1Solute carrier family 4, anion exchanger, member 1112.4TM+
SNCAα-Synuclein isoform NACP11250.3TM+
SPARCSecreted protein, acidic, cysteine-rich precursor23.5Signal++
TFTransferrin precursor222.1Signal++
TLN1Talin 172.0TM++
TNCTenascin C precursor52.8TM+
TNRTenascin R precursor190.4TM+
TPP1Tripeptidyl-peptidase I preproprotein42.5Signal++
VCLVinculin isoform VCL42.2TM+
VIMVimentin223.2TM+
VTNVitronectin precursor34.7Signal++