Table II Ingenuity Pathway Analysis of the differentially expressed membrane proteins associated with major networks and processes (A)

Differentially expressed proteins from supplemental Table IA were used for the analysis and are shown in bold type. Only the top three networks are shown.

Top functionsAssociated moleculesScoreFocus molecules
Cell morphology, cellular development, cell-to-cell signaling and interactionA2M, Akt, ANXA5, Ap1, ATP1A2, calmodulin, CAMP, CD44, CD63, CD74, CD163, CRMP1, EGFR, ERK1/2, F2, focal adhesion kinase, HLA-DR, HP, Hsp27, HSPA5, HSPB1, IQGAP1, KCNQ2, MAPT, p38 MAPK, PLG, PPIB, PRKAR2B, Rac, SNCA, SNCB, SNCG, SPARC, TNC, VTN3326
Cell morphology, cellular development, cancerActin, α-tubulin, APOC3, ATP1B1, CHI3L1, CRIP2, DPYSL2, eotaxin, ERK, FCER1G, FCGR3A, FLNA, hCG, histone h3, IgG, ITGA5, ITGB1, Jnk, LGALS3, MGST1, MSN, MVP, NAMPT, PDGF BB, PODXL, PTPRC, PTX3, RPL10A, S100A11, SLC4A4, TUBB2A, TUBB2C, VCL, VIM, YBX13326
Cellular function and maintenance, cell-to-cell signaling and interaction, hematological system development and function14-3-3, α-actinin, AMPH, ANXA1, APOH, B2M, BCAP31, C3, CALR, CAMK2D, CAMK2G, CANX, CLU, DNM1, Fibrinogen, HLA-A, HLA-B27, HLA-C, ICAM1, IL12 (complex), Immunoglobulin, ITGAM, ITGB2, LDL, LTF, MHC Class I (complex), MPO, NF-κB (complex), PACSIN1, PDIA3, RHOB, SLC2A5, Tap, TCR, TLN12924