Table III Select proteins with significantly decreased resistant:sensitive protein ratios in SkBr3 and BT474
Uniprot IDProtein nameProtein descriptionRatioP value
SkBr3 SILAC experiment(SkBr3R:SkBr3)
B7Z6C9B7Z6C9Transmembrane 9 superfamily protein member 10.15.31 × 10−16
P04264KRT1Keratin, type II cytoskeletal 10.12.21 × 10−9
Q5K4L6SLC27A3Long-chain fatty acid transport protein 30.11.86 × 10−7
O15027SC16AProtein transport protein Sec16A0.28.80 × 10−5
P52735VAV2Guanine nucleotide exchange factor VAV20.33.34 × 10−4
P50454SERPHSerpin H10.36.01 × 10−4
Q8IV73RAPGEF1Rap guanine nucleotide exchange factor (GEF) 10.32.92 × 10−3
Q8WVX9FAR1Fatty acyl-CoA reductase 10.44.19 × 10−3
Q96BI1SLC22A18Solute carrier family 22 member 180.44.25 × 10−3
P36897TGFBR1TGF-beta receptor type-10.45.98 × 10−3
Q9P0V3SH3BP4SH3 domain-binding protein 40.49.28 × 10−3
Q9NYV4CRKRSCell division cycle 2-related protein kinase 70.41.32 × 10−2
P52701MSH6DNA mismatch repair protein Msh60.41.33 × 10−2
A6NJ78METT5D1S-adenosyl-l-methionine-dependent methyltransferase METT5D10.41.49 × 10−2
P15924DESPDesmoplakin0.42.08 × 10−2
Q63HN8RN213RING finger protein 2130.42.20 × 10−2
Q8IUX1T126BTransmembrane protein 126B0.42.52 × 10−2
Q9NVI7ATAD3AATPase family AAA domain-containing protein 3A0.53.03 × 10−2
Q9C0E2XPO4Exportin-40.53.65 × 10−2
P05026ATP1B1Sodium/potassium-transporting ATPase subunit beta-10.53.96 × 10−2
P06703S100A6Protein S100-A60.54.00 × 10−2
Q9UBF2COPG2Coatomer subunit gamma-20.54.04 × 10−2
Q14527HLTFHelicase-like transcription factor0.54.19 × 10−2
Q9HC07TMEM165Transmembrane protein 1650.54.45 × 10−2
BT474 SILAC experiment(BT474R:BT474)
Q6VVX0CYP2R1Vitamin D 25-hydroxylase0.05.03 × 10−23
Q9UK99FBXO3F-box only protein 30.16.74 × 10−16
Q9Y6S9RPS6KL1Ribosomal protein S6 kinase-like 10.17.60 × 10−16
Q8N3P4VPS8Vacuolar protein sorting-associated protein 8 homolog0.11.47 × 10−15
Q59H77CCT3Chaperonin containing TCP1, subunit 3 (gamma) variant (fragment)0.11.27 × 10−12
P81605DCDDermcidin0.13.08 × 10−12
Q13268DHRS2Dehydrogenase/reductase SDR family member 20.13.69 × 10−12
Q15303ERBB4Receptor tyrosine-protein kinase erbB-40.11.93 × 10−11
P02452COL1A1Collagen alpha-1(I) chain0.21.61 × 10−9
Q13332PTPRSReceptor-type tyrosine-protein phosphatase S0.12.52 × 10−9
Q2NKY5Q2NKY5TUBB6 protein0.12.40 × 10−8
Q01813PFKP6-phosphofructokinase type C0.24.06 × 10−8
Q08554DSC1Desmocollin-10.28.77 × 10−7
P00441SODCSuperoxide dismutase [Cu-Zn]0.11.53 × 10−6
Q59GS5PXNPaxillin0.39.06 × 10−6
P10114RAP2ARas-related protein Rap-2a0.22.60 × 10−5
Q9Y5V3MAGED1Melanoma-associated antigen D10.33.56 × 10−5
P27105STOMErythrocyte band 7 integral membrane protein0.33.63 × 10−4
Q6AI12ANR40Ankyrin repeat domain-containing protein 400.35.34 × 10−4
B0I1S2B0I1S2MYH14 variant protein0.31.59 × 10−3
A4D1S0KLRG2Killer cell lectin-like receptor subfamily G member 20.31.66 × 10−3
O95396MOCS3Adenylyltransferase and sulfurtransferase MOCS30.56.82 × 10−3
Q13829TNAP1BTB/POZ domain-containing protein TNFAIP10.41.05 × 10−2
O14974MYPT1Protein phosphatase 1 regulatory subunit 12A0.41.29 × 10−2
P56537EIF6Eukaryotic translation initiation factor 60.51.63 × 10−2
P49915GUAAGMP synthase [glutamine-hydrolyzing]0.51.70 × 10−2
P16615ATP2A2Sarcoplasmic/endoplasmic reticulum calcium ATPase 20.52.20 × 10−2
Q9GZZ1NAT13N-acetyltransferase 130.52.28 × 10−2
P22061PIMTProtein-l-isoaspartate (d-aspartate) O-methyltransferase0.52.34 × 10−2
P55060CSE1LExportin-20.52.57 × 10−2
Q05639EF1A2Elongation factor 1-alpha 20.52.70 × 10−2
Q9HCY8S100A14Protein S100-A140.52.85 × 10−2
Q9Y608LRRF2Leucine-rich repeat flightless-interacting protein 20.53.19 × 10−2
Q92616GCN1L1Translational activator GCN10.53.35 × 10−2
Q96IZ0PAWRPRKC apoptosis WT1 regulator protein0.53.49 × 10−2
B9EGR7ARHGEF5Rho guanine nucleotide exchange factor (GEF) 50.53.71 × 10−2
P33993MCM7DNA replication licensing factor MCM70.54.06 × 10−2
P62993GRB2Growth factor receptor-bound protein 20.54.10 × 10−2
B4E3B6HSPA1AHeat shock 70 kDa protein 10.64.15 × 10−2
P02786TFR1Transferrin receptor protein 10.54.37 × 10−2