Table I Mitochondrial arginine methylproteins with functions in metabolism. Forty-four proteins that either have known functions in mitochondrial metabolism or that physically associate with the mitochondrial respiratome (31, 53) were identified as methylproteins
TriTryp DB numberProtein name# methyl arginines
Tb11.47.00042-oxoglutarate dehydrogenase E1 component, putative4
Tb11.01.35502-oxoglutarate dehydrogenase E2 component, putative1
Tb927.8.25403-ketoacyl-CoA thiolase1
Tb927.8.69703-methylcrotonyl-CoA carboxylase alpha subunit, putative3
Tb927.8.75303,2-trans-enoyl-CoA isomerase1
Tb927.8.26105-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase, putative1
Tb927.1.4490Acetyltransferase, putative Acyl-CoA N-acyltransferase1
Tb10.70.5510 (Tb927.10.2230)Adrenodoxin reductase, putative ferredoxin NADP reductase-like protein2
Tb927.6.4210Aldehyde dehydrogenase, putative1
Tb11.02.1340AMP deaminase, putative1
Tb10.61.2130 (Tb927.10.14550)*ATP-dependent DEAD/H RNA helicase, putative (TbDed1p) associated with complex V2
Tb927.3.1380ATP synthase beta chain, mitochondrial precursor2
Tb10.100.0070 (Tb927.10.180)ATP synthase F1 subunit gamma protein, putative1
Tb927.4.2560Cardiolipin synthetase, putative2
Tb927.2.1560Cyclophilin type peptidyl-prolyl cis-trans isomerase precursor, putative associated with complex I1
Tb927.2.1680Cyclophilin type peptidyl-prolyl cis-trans isomerase precursor, putative associated with complex I1
Tb10.70.5510Ferredoxin NADP reductase-like protein2
Tb09.160.4910Flavoprotein monooxygenase, putative1
Tb11.02.2700Fumarate hydratase class I, putative1
Tb11.02.0440Glycerolphosphate mutase, putative1
Tb927.2.4380Hypothetical protein, conserved 30M24.390 (TbTob55) associated with complex I3
Tb10.70.6930 (Tb927.10.1160)Hypothetical protein, conserved associated with complex I1
Tb927.5.2580Hypothetical protein, conserved associated with complex IV2
Tb11.47.0022Hypothetical protein, conserved associated with complex V1
Tb927.2.3610Hypothetical protein, conserved associated with complex V1
Tb10.70.7760 (Tb927.10.520)Hypothetical protein, conserved associated with complex V1
Tb927.5.2930Hypothetical protein, conserved associated with complex V2
Tb10.70.4980 (Tb927.10.2680)Hypothetical protein, conserved FAD/NAD(P)-binding domain, oxidoreductase1
Tb927.7.910Hypothetical protein, conserved NAD(P)-linked oxidoreductase2
Tb11.0300Hypothetical protein 1 TM domain p27-like1
Tb927.1.730Hypothetical protein, conserved PROKAR lipid attachment/P-loop containing nucleoside triphosphate hydrolases associated with complex I2
Tb10.70.3940 (Tb927.10.3510)Hypothetical protein, conserved Pseudouridine synthase, catalytic domain1
Tb927.4.4300Hypothetical protein, conserved SET domain associated with complex I2
Tb10.70.3640*Hypothetical protein, conserved SET domain associated with respiratome1
Tb927.4.2030*Hypothetical protein, conserved (TbALBA4) associated with complex V7
Tb11.02.2980Hypothetical protein, conserved ubiquinol-cytochrome-c reductase2
Tb11.02.3130Malic enzyme, putative4
Tb927.8.1060Malonyl-CoA decarboxylase, mitochondrial precursor, putative4
Tb927.7.910NAD(P)-linked oxidoreductase2
Tb09.211.4110NADPH–cytochrome p450 reductase, putative2
Tb11.0400p27 protein, putative1
Tb10.389.0890 (Tb927.10.12700)Pyruvate dehydrogenase E1 alpha subunit, putative4
Tb09.211.4700Reiske iron-sulfur protein, mitochondrial precursor1
Tb10.61.0690tRNA pseudouridine synthase A-like protein4
Tb11.02.2980Ubiquinol-cytochrome-c reductase2
Tb10.61.0960 (Tb927.10.15420)S-adenosyl-l-methionine-dependent methyltransferase (C20orf7)1
  • Indicates proteins that exhibited the same methylpeptide and are likely repeat proteins in the genome.

  • * Proteins that have been shown to be cytoplasmic and/or nuclear, but are also reportedly associated with the mitochondrial respiratome.