Table II Cox multivariate regression analysis of prognostic factors of CRKL, FLT1, or CRKL/FLT1 expression for disease-free survival (DFS) and overall survival (OS) in 192 HCC patients
FactorsCRKLFLT1CRKL/FLT1
HRb (95% CIc)p valueHR (95% CI)p valueHR (95% CI)p value
Disease-free survival
    CRKL (low vs. high)1.579 (1.125–2.216)0.008a
    FLT1 (low vs. high)1.275 (0.912–1.783)0.156
    CRKL/FLT1 (others vs. high/high)1.271 (1.043–1.549)0.018a
    Stage (I and II vs. III)1.687 (1.153–2.469)0.007a1.706 (1.161–2.507)0.007a1.679 (1.146–2.458)0.008a
    AFPd (<400 vs. ≥400 ng/ml)1.147 (0.737–1.786)0.5431.076 (0.687–1.686)0.7501.090 (0.699–1.699)0.703
    Major vessel invasion (yes vs. no)1.904 (1.117–3.246)0.018a2.040 (1.204–3.457)0.008a1.954 (1.148–3.325)0.014a
Overall survival
    CRKL (low vs. high)1.747 (1.186–2.573)0.005a
    LT1 (low vs. high)1.289 (0.886–1.876)0.185
    CRKL/FLT1 (others vs. high/high)1.313 (1.052–1.638)0.016a
    Stage (I and II vs. III)1.694 (1.139–2.517)0.009a1.686 (1.130–2.514)0.01a1.687 (1.134–2.509)0.010a
    AFP (<400 vs. ≥400 ng/ml)1.326 (0.857–2.051)0.2051.297 (0.833–2.019)0.2491.280 (0.825–1.984)0.271
    Major vessel invasion (yes vs. no)1.694 (1.054–2.571)0.031a1.881 (1.111–3.185)0.019a1.799 (1.060–3.053)0.029a
  • a p < 0.05.

  • b HR represents hazard ratio.

  • c CI represents confidence interval.

  • d AFP represents α-fetoprotein.