Table I List of “secretion signature” factors in response to 25 mm glucose incubation of MIN6 cells
Protein namesUniprotGene namesRatio normalized high glucose/low glucoseRatio normalized low glucose/high glucoseRatio normalized after si-Gck/si-ctrlNo. of peptides
C-flanking peptide of NPYP57774Npy4.52−2.10−1.265
Insulin-1P01325Ins14.27−1.29−1.455
IGF-IIE9QLW5Igf24.18−2.75−1.477
Carboxypeptidase EQ00493Cpe4.07−2.35−1.1843
Chromogranin-BP16014Chgb3.99−2.18−1.3254
PreprodynorphinO35852mCG_99043.98−2.51−1.2014
Chromogranin-CQ03517Chgc3.98−2.28−1.3153
VGF nerve growth factor inducibleQ0VGU4mCG_180193.96−2.46−1.3039
Neuronal pentraxin receptorQ3UH37Nptxr3.95−1.96−1.2317
Protein-tyrosine phosphatase, receptor type, N polypeptide 2A3KN68Ptprn23.90−2.55−1.1331
Furin homologP63239Att-13.84−2.20−1.2038
Secretogranin IIIP47867Scg33.82−2.46−1.1244
KEX2-like endoprotease 2P21661Nec23.78−2.08−1.0531
C-terminal peptideP12961Scg53.77−2.18−1.1910
Neuronal pentraxin IQ62443Nptx13.73−1.99−0.7618
Receptor-type tyrosine-protein phosphatase-like NE9Q746Ptprn3.70−2.44−1.2216
Ribonuclease 4Q5UCA9Rnase43.63−1.85−1.487
DnaJ (Hsp40) homolog, subfamily B, member 9Q5D0C3Dnajb93.63−1.88−1.3310
Protein OS-9Q8K2C7–1Os93.51−1.77−1.4417
Big LENQ9QXV0Pcsk1n3.51−3.01−1.0713
Lysyl oxidase homolog 2P58022-1Loxl23.31−1.99−1.1229
Peptidyl-α-hydroxyglycine α-amidating lyaseE9QL07Pam3.31−2.37−1.3135
Neuronal pentraxin IIO70340Nptx23.26−1.73−0.8419
Spock1 proteinB2RXY1Spock13.22−2.25−1.4311
AngiogeninP21570Ang3.11−1.80−1.197
Cystatin-3P21460Cst33.09−1.16−1.198
Insulin-2P01326Ins22.97−1.12−1.277
Bone morphogenetic protein 1Q6NZM2Bmp12.94−2.64−1.4013
SPARC/osteonectin, CWCV, and Kazal-like domains proteoglycan 2Q9ER58Spock22.85−0.52−0.8511
Brain-specific receptor-like protein AQ4V9Z5–2Sez6l22.79−0.70−1.2925
GlicentinP55095Gcg2.69−1.60−1.1214
Vitamin D-binding proteinP21614Gc2.59−1.33−1.4618
E-selectin ligand 1Q61543Esl12.54−0.75−1.0641
Golgi membrane protein 1Q91XA2Golm12.38−1.45−1.837
Putative uncharacterized protein Golim4D3YVW2Golim42.35−0.97−1.7912
Pappa2 proteinE9PZ87Pappa22.30−1.66−1.2750
ProsaposinQ3UE29Psap2.30−1.68−0.6118
45-kDa calcium-binding proteinQ61112–1Cab452.16−0.78−1.1622
Ribosomal protein L1Q3U561Rpl10a1.83−1.48−0.6113
Fetuin-BQ9QXC1Fetub1.77−2.13−0.8414
Chondroitin sulfataseQ571E4Galns1.47−0.68−0.9624
Acid ceramidaseQ9WV54Asah1.15−0.52−0.8217
ABPPP12023–1App1.01−0.77−0.8522
Fam3c proteinQ6NSU0D6Wsu176e0.91−1.13−0.939
α-N-Acetylglucosaminidase (Sanfilippo disease IIIB)A2BFA6Naglu0.88−1.02−1.1121
AmylinP12968Iapp0.81−2.25−1.924
γ-Glutamyl hydrolaseB1AWC1Ggh0.71−0.86−0.8111
β-Hexosaminidase subunit βP20060Hexb0.53−0.55−0.7422