Table II Proteins with increased abundance during hypoxic growth
Identified proteinsAccession no.Molecular massFisher's exact test (p value)Normal NSAaHypoxic NSAFLog fold change
Conserved hypothetical proteinRv262332 kDa(0.0000)114−3.81
Acyl-(acyl-carrier protein) desaturase, DesA1Rv0824c39 kDa(0.0000)112−3.58
Hypothetical protein, AcgRv203237 kDa(0.0003)18−3.00
Phosphoribosylaminoimidazole-succinocarboxamide synthase, PurCRv078033 kDa(0.0010)17−2.81
Ketol-acid reductoisomerase, IlvCRv3001c36 kDa(0.0010)17−2.81
Acyl-(acyl-carrier protein) desaturase DesA2Rv109431 kDa(0.0000)212−2.58
Isocitrate lyase, IclRv046747 kDa(0.0033)16−2.58
10-kDa culture filtrate antigen, EsxBRv387411 kDa(0.0100)15−2.32
40-kDa secreted l-alanine dehydrogenase, AldRv278039 kDa(0.0000)29134−2.21
Citrate synthase I, GltA2Rv089648 kDa(0.0320)14−2.00
DNA gyrase subunit B, GyrBRv000578 kDa(0.0320)14−2.00
Transcription termination factor ρRv129765 kDa(0.0000)415−1.91
Iron-regulated heparin-binding hemagglutinin, HbhARv047522 kDa(0.0004)311−1.87
ATP synthase α chain, AtpARv130859 kDa(0.0011)411−1.46
Macrolide-transport ATP-binding protein ABC transporterRv2477c62 kDa(0.0005)513−1.38
6-Phosphofructokinase, PfkARv3010c37 kDa(0.0140)59-0.85
Fatty-acid oxidation protein, FadBRv086076 kDa(0.0010)1017−0.77
Heat shock protein, HspXRv2031c16 kDa(0.0000)133223−0.75
Conserved hypothetical proteinRv173811 kDa(0.0019)1016−0.68
Bifunctional polyribonucleotide nucleotidyltransferase, GpsIRv2783c80 kDa(0.0026)1318−0.47
Adenosylhomocysteinase, SahHRv3248c54 kDa(0.0000)4553−0.24
Iron-regulated aconitate hydratase, AcnRv1475c102 kDa(0.0490)1011−0.14
  • a A value of 1 indicates an NSAF of 0.