Table I Functional classification of the significantly altered proteins from CacyBP-OE data set. These proteins have met the criteria (i.e., unused protein score > 1.3 and change in expression level of at least 1.44-fold for HCT116-CacyBP OE vs. HCT116-Control cell) as defined in the “materials and method” as well as “results” section
Unused Protein score% Sequence CoverageAccession NumberNameSpeciesPeptides (95%)Expression patterniTRAQ Ratio (Mean± S.E.)
Proteins involved in cellular proliferation
    4.3145.2IPI00946824.1FXN Uncharacterized protein960620.43 ± 0.05
    12.5122.1IPI00795482.1STAT1 83 kDa protein960682.44 ± 0.32
Proteins involved in cell Migration
    23.117.1IPI00215995.1Isoform 1 of Integrin alpha-39606181.49 ± 0.18
    14.8623.9IPI00921401.1Isoform 9 of Integrin alpha-69606112.56 ± 0.04
    10.9924IPI00555991.2Isoform 2 of Integrin alpha-V960691.89 ± 0.15
    48.2335.1IPI00220847.2Isoform Beta-4D of Integrin beta-49606341.47 ± 0.03
    1037.8IPI00719669.4Myosin regulatory light chain MRCL2960651.52 ± 0.1
    4.0741.6IPI00032313.1S100A4 Protein960622.63 ± 0.2
    1273.2IPI00297714.2Gamma-synuclein960692.32 ± 0.08
    12.5122.1IPI00795482.1STAT1 83 kDa protein960682.45 ± 0.32
    415.4IPI00219301.7Myristoylated alanine-rich C-kinase substrate9606243.71 ± 21.65
    22.2276.3IPI00219219.3Galectin-19606330.62 ± 0.01
Proteins involved in cellular invasion
    45.8IPI01014165.1COL18A1 Uncharacterized protein960621.83 ± 0.04
    10.9924IPI00555991.2Isoform 2 of Integrin alpha-V960691.89 ± 0.15
    48.2335.1IPI00220847.2Isoform Beta-4D of Integrin beta-49606341.47 ± 0.03
    415.4IPI00219301.7Myristoylated alanine-rich C-kinase substrate9606243.71 ± 21.65
    16.449.1IPI00647915.1TAGLN2 24 kDa protein9606131.73 ± 0.10
    6.1155.3IPI01021488.1CBX5, 22 kDa protein960650.54 ± 0.1
Proteins engaged in cellular adhesion
    12.1425.6IPI00395605.4ARHGEF1 Isoform 3 of Rho guanine nucleotide exchange factor 1960670.65 ± 0.07
    11.8929.5IPI00301058.5VASP Vasodilator-stimulated phosphoprotein9606110.59 ± 0.02
Proteins involved in caveolar mediated endocytosis
    23.117.1IPI00215995.1Isoform 1 of Integrin alpha-39606181.49 ± 0.18
    14.8623.9IPI00921401.1Isoform 9 of Integrin alpha-69606112.56 ± 0.04
    10.9924IPI00555991.2Isoform 2 of Integrin alpha-V960691.89 ± 0.15
    48.2335.1IPI00220847.2Isoform Beta-4D of Integrin beta-49606341.47 ± 0.03
Proteins involved in ARP-WASP mediated actin nucleation
    23.117.1IPI00215995.1Isoform 1 of Integrin alpha-39606181.49 ± 0.18