Table I SLP76 interactome in resting BMMC. Proteins were identified in four affinity purifications of SLP76OST complexes in resting cells. Listed molecules were enriched at least fourfold in nonactivated SlpOST/OST compared to Slp+/+ BMMC (OST− vs WT−). The significance (p < 10−3) of enrichment (OST−/WT− ratio) was determined using student's t-test. UniProt Accession numbers, protein symbols and molecular function are also shown
Protein symbolProtein nameUniProt AccFunctionRatio
Resting BMMC
    GRAP2GRB2-related adaptor protein 2O89100Adapter Protein513
    RABE1Rab GTPase-binding effector protein 1O35551GTPase activation192
    RHG27Rho GTPase-activating protein 27A2AB59GTPase activation72