Table I Substrate candidates of SYK kinase identified in both reciprocal in vitro and in vivo methods
AccessionsGene nameProtein namePhosphorylation sites
P52565ARHGDIARho GDP dissociation inhibitor (GDI) alphaY156
Q9P0L7BTKBruton agammaglobulinemia tyrosine kinaseY551
Q9UJU6DBNLDrebrin-likeY162
Q53H88DCTN2Dynactin 2 (p50)Y91
Q14318FKBP8FK506 binding protein 8, 38kDaY351
Q8N6F7GCET2Germinal center expressed transcript 2Y148
Q6GVN4HCA59Hepatocellular carcinoma-associated antigen 59Y68
P14317HCLS1Hematopoietic cell-specific Lyn substrate 1Y103, Y140, Y222
Q9BW71HIRIP3HIRA interacting protein 3Y111
Q86X89MAP1BMicrotubule-associated protein 1BY1044, Y1062, Y1337, Y1410, Y1889, Y1921, Y1938, Y1940, Y1957, Y2025
P23511NFYANuclear transcription factor Y, alphaY237
Q9NWQ8PAG1Phosphoprotein associated with glycosphingolipid microdomains 1Y163, Y417
Q9NWS0PIH1D1PIH1 domain containing 1Y194
P16885PLCG2Phospholipase C, gamma 2 (phosphatidylinositol-specific)Y759
Q06124PTPN11Protein tyrosine phosphatase, non-receptor type 11Y580
Q9NQC3RTN4Reticulon 4Y718
Q53HM6SF3A3Splicing factor 3a, subunit 3, 60kDaY479
Q9BSV4SFPQSplicing factor proline/glutamine-richY488
O00193SMAPSmall acidic proteinY84
P31948STIP1Stress-induced-phosphoprotein 1Y354
Q99426TBCBTubulin folding cofactor BY98
Q15785TOMM34Translocase of outer mitochondrial membrane 34Y54
Q5JP53TUBBTubulin, beta class IY33
Q96HX0TUBB4BTubulin, beta 4B class IVbY50
Q5JRS2UBA1Ubiquitin-like modifier activating enzyme 1Y106