Table II List of sixteen candidate biomarkers with score ≥ 3a
Protein NamesGene NameMW kDaPDAC TissuesbmRNA fold↑AscitescLFQ scoredTissue scoremRNA scoreAscites scoreTotal score
DesmoplakinDSP33230.941321014
Laminin subunit gamma-2LAMC213128.3611204
Golgi membrane protein 1GP7346.322.61411114
Desmoglein-2DSG212222.321011114
Tetraspanin-1TSPAN126.324.85111114
MesothelinMSLN71.526.1211204
Alkaline phosphatase, placental-likeALPPL57.420.7721003
Cadherin-17CDH1792.221.9421003
Mucin-13MUC1354.612.4520103
S100 calcium-binding protein A14S100A1411.732.4611103
FXYD ion transport regulator 3FXYD315.234.6711103
AfadinAF620841.3012003
C-type lectin domain family 13 member BCLEC13B21634.0011103
Tetraspanin-8TSPAN82623.3211103
Trophoblast glycoproteinTPBG4643.1602103
Mucin-4MUC454225.3501203
  • a For scoring systems see text and Fig. 2.

  • b Identified in PDAC tissues out of 4 tested.

  • c Number of unique peptides identified in ascites by proteomic analysis (see Ref. 7).

  • d LFQ, label-free quantitation; the definition of LFQ and calculation of ratio of cancer/normal is described in the text.