Table II Proteases identified in the venom gland of Conus geographus by transcriptome sequencing sorted after number of reads. Uniprot accession numbers of most homologous proteins are provided
AccessionMost homologous proteinSpeciesReadsDomains
EKC20550Tripeptidyl-peptidase 2Crassostrea gigas474Peptidase S8
EKC26094Astacin like-1 (Blastula protease)Crassostrea gigas145M12A
Q9D958Signal peptidase complex subunit 1Mus musculus68SPC12
Q5BJI9Signal peptidase complex subunit 2Danio rerio28SPC25
Q3SZ71Mitochondrial-processing peptidaseBos taurus24M16
Q9VCA9Signal peptidase complex subunit 3Drosophila melanogaster21SPC22
P42893Endothelin-converting enzyme 1Rattus norvegicus20M13
P42674Blastula protease 10Paracentrotus lividus16M12A, MMP
P53634Dipeptidyl-peptidase 1Homo sapiens13Cathepsin C
P09648Cathepsin L1Gallus gallus11Peptidase C1A
P50579Methionine aminopeptidase 2Homo sapiens10APP-MetAP
EKC19359Virulence metalloproteaseCrassostrea gigas8M4
P28840Neuroendocrine convertase 1Rattus norvegicus7S8, S53
Q32LQ0Glutamyl aminopeptidaseBos taurus7DUF
Q10714Angiotensin-converting enzymeDrosophila melanogaster7M2
P16519Neuroendocrine convertase 2Homo sapiens5Convertase P
P78562Phosphate-regulating endopeptidaseHomo sapiens4M13
P13277Digestive cysteine proteinase 1Homarus americanus4Peptidase C1A
Q03168Lysosomal aspartic proteaseAedes aegypti4Cathepsin D
Q4VC17MetalloproteinaseMus musculus3M12B
Q26563Cathepsin CSchistosoma mansoni3C1 Peptidase
P55110Zinc metalloproteinase mspALegionella longbeachae3GluZincin
XP_002738143Caseinolytic peptidaseSaccoglossus kowalevskii3ClpP
P37892Carboxypeptidase ELophius americanus3M14
Q80W54CAAX prenyl protease 1 homologMus musculus2M48
Q8NDH3Aminopeptidase NPEPL1Homo sapiens2M17
A6H611Mitochondrial intermediate peptidaseMus musculus2M3
Q20176Zinc metalloproteinase nas-39Caenorhabditis elegans2ZnMc
A6QPT7ER aminopeptidase 2Bos taurus2M1
Q80Z60Endothelin-converting enzyme 2Mus musculus2M13
Q22523Zinc metalloproteinase T16A9.4Caenorhabditis elegans2M13
Q9R014Cathepsin JMus musculus2C1 Peptidase
Q26534Cathepsin LSchistosoma mansoni2Peptidase C1A
P70669Metalloendopeptidase homolog PEXMus musculus2M13
P79171Aminopeptidase NFelis catus1DUF
Q0VGW4ER metallopeptidase 1Xenopus laevis1M28
Q5G269NeurotrypsinPongo pygmaeus1Tryp-SPc
P12955Xaa-Pro dipeptidaseHomo sapiens1APP-MetAP
O75976Carboxypeptidase DHomo sapiens1M14 N/E
P05689Cathepsin ZBos taurus1C1 Peptidase
Q5R432Cytosolic non-specific dipeptidasePongo abelii1M20
P42658Dipeptidyl aminopeptidase-like 6Homo sapiens1N/A
P0C1T0Membrane metallo-endopeptidase-like 1Rattus norvegicus1M13
Q9H3G5Serine carboxypeptidaseHomo sapiens1S10
Q9N2V2Zinc metalloproteinase nas-30Caenorhabditis elegans1M12A
Q4LAL9Cathepsin DCanis familiaris1Cathepsin D
EKC42374Aminopeptidase NCrassostrea gigas1M1
Q5XIB4Ufm1-specific protease 2Rattus norvegicus1N/A
Q2HJH1Aspartyl aminopeptidaseBos taurus1M18, M20, M28, M42
Q2KJ83Carboxypeptidase NBos taurus1M14
O35186Cathepsin KRattus norvegicus1C1 Peptidase
P00747PlasminogenHomo sapiens1KR
A6NEC2Puromycin-sensitive aminopeptidaseHomo sapiens1M1
P59110Sentrin-specific protease 1Mus musculus1N/A