Table II p values for significant associations between genetic polymorphisms and glycan structures or traits obtained by different methods. Bold text indicates that the p value reaches genome wide significance (p < 5 × 10−8)
Glycan Structure Or TraitGenes in Associated RegionSNPAssociation p-Value
UPLC-FLRMALDI-TOF-MS (IgG1)MALDI-TOF-MS (IgG2&3)LC-ESI-MS (IgG1)LC-ESI-MS (IgG2&3)xCGE-LIF
FA2BG1aSMARCB1; DERL3rs96203261.47E-101.15E-071.70E-061.63E-084.11E-101.11E-10
1.54E-047.46E-06
FA2G1S1ST6GAL1rs67642792.80E-220.25564.36E-101.13E-281.15E-271.60E-18
FGS/(FG+FGS)ST6GAL1rs67642791.14E-200.01541.86E-124.87E-121.64E-254.83E-18
FGS/(F+FG+FGS)ST6GAL1rs67642793.25E-040.10081.97E-041.21E-051.44E-093.82E-07
FG1S1/(FG1+FG1S1)ST6GAL1rs67642791.50E-220.39419.60E-212.51E-331.31E-405.61E-22
FG2S1/(FG2+FG2S1+FG2S2)ST6GAL1rs67642791.54E-361.26E-113.49E-234.67E-261.37E-321.71E-37
  • a This glycan structure is measured as two isomers with UPLC-FLR and xCGE-LIF (FA2[6]BG1, with galactose on the 6-arm and FA2[3]BG1, with galactose on the 3-arm), but as only one mass in the MS methods.