Table II Univariate and multivariate analyses of cFTH1 and nFTH1 related to metastasis-free survival (n = 147)
TNBC cohort on TMAUnivariateMultivariate
VariablesHazard ratio (95% CI)p valueHazard ratio (95% CI)p value
(A) Conventional prognostic factors
    Age (Continuous variable)1.00 (0.98–1.02)0.9131.02 (0.98–1.05)0.356
    Menopausal status (Post- versus Pre-menopausal)0.85 (0.49–1.48)0.5710.56 (0.21–1.49)0.244
    Tumor size (>2 cm and unknown versus ≤2 cm)1.69 (0.94–3.02)0.0781.89 (1.04–3.43)0.035
    Tumor grade (Grade 3 and unknown versus Grade 1 and 2)0.57 (0.30–1.10)0.0930.56 (0.29–1.10)0.092
(B) FTH1 expression
    cFTH1 expression (>75% versus ≤75% staining)0.43 (0.24–0.79)0.0060.42 (0.23–0.78)0.006a
    nFTH1 expression (>1% versus ≤1% staining)2.52 (1.07–5.92)0.0352.27 (0.95–5.44)0.065a
  • a cFTH1 and nFTH1 staining were separately added into conventional prognostic factors for multivariate assessment.