Table II Univariate and multivariate analyses of cFTH1 and nFTH1 related to metastasis-free survival (n = 147)

TNBC cohort on TMA	Univariate		Multivariate
Variables	Hazard ratio (95% CI)	p value	Hazard ratio (95% CI)	p value
(A) Conventional prognostic factors
Age (Continuous variable)	1.00 (0.98–1.02)	0.913	1.02 (0.98–1.05)	0.356
Menopausal status (Post- versus Pre-menopausal)	0.85 (0.49–1.48)	0.571	0.56 (0.21–1.49)	0.244
Tumor size (>2 cm and unknown versus ≤2 cm)	1.69 (0.94–3.02)	0.078	1.89 (1.04–3.43)	0.035
Tumor grade (Grade 3 and unknown versus Grade 1 and 2)	0.57 (0.30–1.10)	0.093	0.56 (0.29–1.10)	0.092
(B) FTH1 expression
cFTH1 expression (>75% versus ≤75% staining)	0.43 (0.24–0.79)	0.006	0.42 (0.23–0.78)	0.006^{^a}
nFTH1 expression (>1% versus ≤1% staining)	2.52 (1.07–5.92)	0.035	2.27 (0.95–5.44)	0.065^{^a}

↵^a cFTH1 and nFTH1 staining were separately added into conventional prognostic factors for multivariate assessment.