Table III Percentage of newly synthesized guanidine-insoluble ECM proteins present in control and bleomycin-induced fibrotic lung tissue after 1 and 3 weeks of label. Values represent mean ± S.D. (n = 3) where protein data were available from three distinct biological samples
ProteinAccession numberAverage F control, 1 week (%)Average F bleomycin, 1 week (%)Average F control, 3 weeks (%)Average F bleomycin, 3 weeks (%)
Collagen α-1(I) chainaP110875.0 ± 0.912.0 ± 5.17.4 ± 1.257.3 ± 8.5
Collagen α-2(I) chainaQ011495.2 ± 1.011.9 ± 4.18.4 ± 1.858.2 ± 8.7
Collagen α-1(III) chainaP081216.2 ± 0.811.8 ± 2.99.0 ± 1.551.8 ± 7.1
Collagen α-1(IV) chainaP024638.7 ± 1.413.1 ± 1.019.4 ± 1.057.6 ± 7.9
Collagen α-2(IV) chainaP081228.8 ± 1.014.9 ± 1.120.4 ± 0.859.1 ± 9.7
Collagen α-1(V) chainaO882075.8 ± 1.713.0 ± 2.011.8 ± 2.157.0 ± 8.4
Collagen α-1(VI) chainbQ0485712.5 ± 2.929.8 ± 5.426.4 ± 4.178.8 ± 6.6
Collagen α-2(VI) chainbQ0278812.5 ± 2.828.6 ± 4.926.1 ± 3.574.2 ± 7.4
ElastinaP543204.7 ± 1.111.9 ± 7.08.5 ± 1.274.4 ± 11.6
EMILIN-1bQ99K4127.2 ± 0.554.7 ± 5.658.1 ± 3.784.7 ± 0.3
Fibrillin-1bQ6155411.3 ± 1.225.9 ± 6.322.5 ± 2.383.6 ± 4.2
Fibulin-5aQ9WVH97.7 ± 1.67.0 ± 1.814.7 ± 0.745.3 ± 0.6
Laminin subunit α-3aQ617899.7 ± 0.69.9 ± 2.922.6 ± 0.954.1 ± 13.6
Laminin subunit α-5aQ610018.2 ± 0.69.8 ± 2.213.8 ± 0.635.5 ± 6.5
Laminin subunit β-2aQ612926.8 ± 0.47.7 ± 2.013.2 ± 0.533.3 ± 6.1
Laminin subunit β-3aQ6108712.6 ± 0.18.6 ± 1.722.0 ± 2.745.6 ± 5.0
Laminin subunit γ-1aP024687.4 ± 0.48.5 ± 1.913.4 ± 0.535.4 ± 5.4
Microfibrillar-associated protein 2aP5500210.0 ± 2.413.523.9 ± 1.364.4 ± 7.8
NephronectinaQ91V8810.3 ± 0.68.9 ± 2.722.4 ± 1.734.7 ± 3.1
PeriostinaQ6200934.7 ± 4.236.5 ± 11.468.4 ± 2.192.1 ± 3.2
PerlecanaQ0579313.1 ± 0.215.1 ± 4.129.1 ± 1.460.1 ± 2.7
  • a p < 0.05 at 3 weeks only.

  • b p < 0.05 at both time points.