Table I Proteins differentially expressed in mouse cerebellum upon cGKI knockout
AccessionGene nameDescriptioncGKI-KO/WTS.D.Number of unique peptides
Q60590Orm1α-1-acid glycoprotein 123.451.465
Q91X72HpxHemopexin9.272.4622
Q8K0E8FgbFibrinogen β chain6.210.9022
Q8VCM7FggFibrinogen γ chain5.751.5720
Q8CGV2Tph2Tryptophan 5-hydroxylase 26.083.8111
Q3UHL1CamkvCaM kinase-like vesicle-associated protein4.671.0011
P06909CfhComplement factor H4.241.0818
Q5DTY9Kctd16BTB/POZ domain-containing protein KCTD164.541.305
Q9R111GdaGuanine deaminase3.460.7110
O35668Hap1Huntingtin-associated protein 13.520.207
O08677Kng1Kininogen-13.500.7513
Q9QUG9Rasgrp2RAS guanyl-releasing protein 23.460.856
P01029C4bComplement C4-B3.161.118
Q8K3E5Ahi1Jouberin3.050.4325
P97467PamPeptidyl-glycine α-amidating monooxygenase3.150.9112
P50153Gng4Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit γ-43.090.841
P20918PlgPlasminogen3.040.9315
Q61704Itih3Inter-α-trypsin inhibitor heavy chain H32.900.5611
Q61147CERUCeruloplasmin3.000.8722
Q91ZP9Necab2N-terminal EF-hand calcium-binding protein 23.191.175
Q91XV3Basp1Brain acid soluble protein 13.020.6714
P11276Fn1Fibronectin2.790.6530
P01027C3Complement C32.920.9954
Q921I1TRFESerotransferrin2.840.8138
Q9DB26Phyhd1Phytanoyl-CoA dioxygenase domain-containing protein 12.840.812
Q91WP6Serpina3nSerine protease inhibitor A3N2.850.653
Q8BHH2Rab9bRas-related protein Rab-9B2.911.214
Q8CHT1NgefEphexin-12.650.593
Q61423Kcna4Potassium voltage-gated channel subfamily A member 42.710.891
Q03517Scg2Secretogranin-22.730.4819
O35526Stx1aSyntaxin-1A2.620.4411
Q9CZS1Aldh1b1Aldehyde dehydrogenase X, mitochondrial2.640.427
D3YVF0Akap5A-kinase anchor protein 52.520.427
Q60673PtprnReceptor-type tyrosine-protein phosphatase-like N2.750.836
Q9WTR5Cdh13Cadherin-132.540.529
Q9WUC3Ly6hLymphocyte antigen 6H2.520.064
Q01097Grin2bGlutamate [NMDA] receptor subunit ϵ-22.410.505
Q9QXV0Pcsk1nProSAAS2.590.539
Q68ED2Grm7Metabotropic glutamate receptor 72.371.014
P06728Apoa4Apolipoprotein A-IV2.370.8714
Q3TW96Uap1l1UDP-N-acetylhexosamine pyrophosphorylase-like protein 12.450.878
P16460Ass1Argininosuccinate synthase2.320.188
P31324Prkar2bcAMP-dependent protein kinase type II-β regulatory subunit2.270.3213
Q68FM6Elfn2Protein phosphatase 1 regulatory subunit 292.250.265
P19221THRBProthrombin2.340.887
O54901Cd200OX-2 membrane glycoprotein2.320.503
Q61838A2mα-2-macroglobulin2.190.6239
P48320Gad2Glutamate decarboxylase 22.200.3714
Q921X9Pdia5Protein disulfide-isomerase A52.320.963
P80560Ptprn2Receptor-type tyrosine-protein phosphatase N22.090.2716
P29699Ahsgα-2-HS-glycoprotein2.311.234
Q61247Serpinf2α-2-antiplasmin2.060.685
Q01065Pde1bCalcium/calmodulin-dependent 3′,5′-cyclic nucleotide phosphodiesterase 1B2.090.5812
Q8BLR2Cpne4Copine-42.080.535
P31650Slc6a11Sodium- and chloride-dependent GABA transporter 31.970.2811
Q60771Cldn11Claudin-112.040.663
Q8R5A6Tbc1d22aTBC1 domain family member 22A2.010.677
Q62188Dpysl3Dihydropyrimidinase-related protein 31.900.0817
P49025CitCitron Rho-interacting kinase1.940.4515
O54990Prom1Prominin-11.910.464
Q2M3X8Phactr1Phosphatase and actin regulator 11.850.415
Q9R226Khdrbs3KH domain-containing, RNA-binding, signal transduction-associated protein 31.980.793
O35495Cdk14Cyclin-dependent kinase 141.960.632
P84075HpcaNeuron-specific calcium-binding protein hippocalcin1.860.495
Q8R5M8Cadm1Cell adhesion molecule 11.830.197
P70392Rasgrf2Ras-specific guanine nucleotide-releasing factor 21.900.567
Q5XG69Fam169aProtein FAM169A1.800.139
P70699GaaLysosomal α-glucosidase1.790.3714
Q61553Fscn1Fascin1.750.1215
P07356Anxa2Annexin A21.780.2115
Q80TL4Kiaa1045Protein KIAA10451.770.3913
O89026Robo1Roundabout homolog 11.760.135
O08532Cacna2d1Voltage-dependent calcium channel subunit α-2/δ-11.800.4221
Q5RJG7Ispd2-C-methyl-d-erythritol 4-phosphate cytidylyltransferase-like protein1.730.034
O35633Slc32a1Vesicular inhibitory amino acid transporter1.730.1610
Q8BLE7Slc17a6Vesicular glutamate transporter 21.730.377
Q9EQF6Dpysl5Dihydropyrimidinase-related protein 51.730.1126
A2ALU4Shroom2Protein Shroom21.730.1815
O55091ImpactProtein IMPACT1.820.5413
Q61599ArhgdibRho GDP-dissociation inhibitor 21.740.356
P36552CpoxCoproporphyrinogen-III oxidase, mitochondrial1.700.228
Q3UUG6Tbc1d24TBC1 domain family member 241.700.029
Q66L44DosProtein Dos1.690.103
Q922J6Tspan2Tetraspanin-21.690.143
Q8BR92Palm2Paralemmin-21.690.139
Q9CX80CygbCytoglobin1.680.1910
Q8BYJ6Tbc1d4TBC1 domain family member 40.630.0516
Q99JP6Homer3Homer protein homolog 30.610.1121
Q69ZX8Ablim3Actin-binding LIM protein 30.600.0412
Q8BYR5Cadps2Calcium-dependent secretion activator 20.600.0834
P08414Camk4Calcium/calmodulin-dependent protein kinase type IV0.610.0921
Q8R071ItpkaInositol-trisphosphate 3-kinase A0.580.0720
Q6NSW3SphkapA-kinase anchor protein SPHKAP0.600.0926
Q91ZH7Abhd3Abhydrolase domain-containing protein 30.580.106
Q9QUR8Sema7aSemaphorin-7A0.580.0712
Q0VEJ0Cep76Centrosomal protein of 76 kDa0.590.1319
Q9JJZ2Tuba8Tubulin α-8 chain0.570.077
P25911LynTyrosine-protein kinase Lyn0.560.117
Q3UH99Shisa6Protein shisa-6 homolog0.560.1111
P18653Rps6ka1Ribosomal protein S6 kinase α-10.580.1217
Q6WQJ1DaglaSn1-specific diacylglycerol lipase α0.540.1014
Q64338Pde1cCalcium/calmodulin-dependent 3′,5′-cyclic nucleotide phosphodiesterase 1C0.530.105
Q5F226Fat2Protocadherin Fat 20.560.1937
Q8QZT2CA096Uncharacterized protein C1orf96 homolog0.530.117
Q80YX1TncTenascin0.500.0345
P55088Aqp4Aquaporin-40.510.252
Q64518Atp2a3Sarcoplasmic/endoplasmic reticulum calcium ATPase 30.520.2023
Q8CG03Pde5acGMP-specific 3′,5′-cyclic phosphodiesterase0.540.169
Q9ERY9ORF11Probable ergosterol biosynthetic protein 280.530.203
Q9EQK7IcmtProtein-S-isoprenylcysteine O-methyltransferase0.540.243
Q9ERQ8Ca7Carbonic anhydrase 70.490.114
Q64444Ca4Carbonic anhydrase 40.520.198
P06537Nr3c1Glucocorticoid receptor0.490.216
P68433Hist1h3aHistone H3.10.400.035
P62806Hist1h4aHistone H40.350.019
P0C605Prkg1cGMP-dependent protein kinase 10.010.0011