Table II Glycosylation changes during pregnancy (first versus third trimester) and immediately after delivery (third trimester versus 6 weeks postpartum)
IgGFcFab
Mean (%)S.D. (%)p valueaMean (%)S.D. (%)p valueaMean (%)S.D. (%)p valuea
Galactosylation
    trim172.605.4674.255.8394.952.07
    trim375.635.75<0.000176.685.71<0.000194.332.280.1790
    6wkpp67.715.40<0.000168.835.38<0.000194.162.480.3720
Neutral glycosylation
    trim174.714.6576.154.936.542.44
    trim372.035.06<0.000174.725.260.00157.072.600.3507
    6wkpp77.533.79<0.000180.073.93<0.00017.613.010.1396
Monosialylation
    trim121.884.0323.164.9237.774.57
    trim324.144.40<0.000124.565.280.001236.834.710.0025
    6wkpp19.103.21<0.000119.323.93<0.000140.994.70<0.0001
Disialylation
    trim13.410.990.690.4755.696.40
    trim33.841.040.00110.730.670.698756.096.550.0674
    6wkpp3.370.940.00230.610.370.081751.406.950.0001
Fucosylation
    trim192.442.5294.492.2867.635.84
    trim392.192.900.304494.062.450.028866.977.110.1354
    6wkpp92.662.870.001794.652.320.000170.026.900.0017
Bisecting GlcNAc
    trim111.072.238.331.7239.397.32
    trim311.212.280.43008.401.740.963737.407.980.0206
    6wkpp13.072.52<0.00019.882.12<0.000145.357.150.0001
High mannose
    trim10.200.040.070.063.401.91
    trim30.240.080.01040.080.040.15803.902.140.2322
    6wkpp0.220.060.02420.080.040.25633.712.030.8076
α2,3 sialic acid
    trim10.170.030.160.072.170.61
    trim30.190.040.00020.170.050.03232.240.650.0276
    6wkpp0.150.03<0.00010.130.04<0.00011.870.480.0010
α2,6 sialic acid
    trim114.182.6612.112.4472.404.20
    trim315.712.890.000112.832.620.001872.264.210.7369
    6wkpp12.772.22<0.000110.141.95<0.000170.024.690.0007
  • a Wilcoxon sign-ranked test p values < 0.05 are highlighted in bold and considered significant. The statistical test was used to make a pairwise comparison of the first and third trimesters (trim1 and trim3, respectively) and of the third trimester versus 6 weeks postpartum (6wkpp).