Table I Fc and Fab were differentially glycosylated, as illustrated by the means and S.E. values of glycosylation features of IgG from healthy individuals 26 to 52 weeks after delivery. p values were obtained via Wilcoxon sign-ranked test
IgG (mean%; S.E.) n = 28Fc (mean%; S.E.) n = 28Fab (mean%; S.E.) n = 25p
Galactosylation66.59 (1.08)67.41 (1.19)94.33 (0.44)<0.0001
N78.40 (0.70)81.16 (0.77)7.42 (0.53)<0.0001
S118.35 (0.60)18.23 (0.76)40.31 (0.72)<0.0001
S23.24 (0.17)0.61 (0.08)52.27 (1.08)<0.0001
Fucosylation91.90 (0.57)94.44 (0.39)69.47 (1.42)<0.0001
Bisection12.83 (0.46)9.84 (0.34)45.34 (1.38)<0.0001
High mannose0.21 (0.01)0.08 (0.01)3.60 (0.37)<0.0001
α2,3-linked sialic acids (%)0.2 (0.01)0.1 (0.01)1.88 (0.10)<0.0001
α2,6-linked sialic acids (%)12.3 (0.41)9.60 (0.38)70.55 (0.76)<0.0001