Table III Summary of HLA-B27 subtype features
SubtypeAS associationResidue 116FoldingaThermostabilityaPC residues
B*27:02YesDSlowHighY, Nonpolar
B*27:03bNot knownDFastbLowbBasic, Y, Nonpolar
B*27:04YesDSlowHighY, Nonpolar
B*27:05YesDSlowHighBasic, Y, Nonpolar
B*27:06NoYFastLowNonpolar
B*27:07YesYFastLowNonpolar
B*27:09NoHFastLowNonpolar
  • a Data from (58).

  • b B*27:03 differs from all other subtypes by the Y59H change in the A pocket. The influence of this change on folding and thermostability sets B*27:03 apart from other subtypes in the correlation of these features with residue 116.