Table I List of 333 regulated proteins in 4 PMI patient samples using iTRAQ workflow
Uniprot accession numberGene symbolProtein nameLog2 iTRAQ ratio (average of 4 PMI patients)Moderated F-test p valueaClusterb
10min vs. BL1hr vs. BL4hr vs. BL
Q9UPZ6THSD7AThrombospondin type-1 domain-containing protein 7A0.9070.7550.0222.06E-051
Q9C0I4THSD7BThrombospondin type-1 domain-containing protein 7B0.6690.5740.0408.12E-031
Q8IUX7AEBP1Adipocyte enhancer-binding protein 11.2150.868−0.0821.17E-031
Q8N436CPXM2Inactive carboxypeptidase-like protein X21.9861.447−0.2342.28E-021
Q02818NUCB1Nucleobindin-10.7130.571−0.0501.09E-021
P05164–3MPOIsoform H7 of Myeloperoxidase0.9240.7600.1161.21E-041
P19801–2AOC1Isoform 2 of Amiloride-sensitive amine oxidase [copper-containing]1.3831.2980.1552.06E-051
P02549SPTA1Spectrin alpha chain, erythrocytic 10.4080.4050.2096.68E-031
Q12906–7ILF3Isoform 7 of Interleukin enhancer-binding factor 30.1800.1690.0544.45E-021
P11150LIPCHepatic triacylglycerol lipase1.1861.3470.1505.93E-051
P19883FSTFollistatin1.1870.9440.0193.59E-051
P08294SOD3Extracellular superoxide dismutase [Cu-Zn]0.7020.5790.0115.07E-031
Q8N474SFRP1Secreted frizzled-related protein 11.3720.9010.0818.71E-051
P80303–2NUCB2Isoform 2 of Nucleobindin-20.5180.4480.1331.02E-021
P21741MDKMidkine2.3411.6550.2081.21E-041
P10646TFPITissue factor pathway inhibitor0.4740.523−0.0254.28E-021
O95631NTN1Netrin-10.7990.6410.1218.03E-041
P25940COL5A3Collagen alpha-3(V) chain0.5470.3650.0193.96E-021
P21246PTNPleiotrophin2.2091.9060.3381.11E-041
P02776PF4Platelet factor 41.3081.2510.4132.81E-021
P10720PF4V1Platelet factor 4 variant1.2611.1490.4152.09E-021
P20827EFNA1Ephrin-A10.3600.3550.0451.83E-021
Q9BY76ANGPTL4Angiopoietin-related protein 40.6090.3970.2292.50E-021
Q15109–3AGERIsoform 3 of Advanced glycosylation end product-specific receptor0.5530.366−0.0402.97E-021
O43508TNFSF12Tumor necrosis factor ligand superfamily member 120.7140.467−0.0644.95E-021
P02788LTFLactotransferrin0.3290.2100.1402.09E-021
Q99584S100A13Protein S100-A131.1311.0030.1269.07E-031
P18827SDC1Syndecan-10.3120.2970.1755.58E-031
O95969SCGB1D2Secretoglobin family 1D member 21.3020.3590.3693.40E-021
E7EN11CACNB4Voltage-dependent l-type calcium channel subunit beta-40.4970.3770.3332.65E-021
P04040CATCatalase0.0900.3120.3603.96E-022
Q13228–4SELENBP1Isoform 4 of Selenium-binding protein 10.0500.2460.2944.76E-022
P00558PGK1Phosphoglycerate kinase 10.1720.6430.7094.54E-042
P48147PREPProlyl endopeptidase0.1130.3940.4082.75E-032
P07951–2TPM2Isoform 2 of Tropomyosin beta chain0.3380.5490.5176.83E-032
P07951TPM2Tropomyosin beta chain0.3160.5100.4622.70E-022
P06733ENO1Alpha-enolase0.1120.2620.3401.81E-022
P02144MBMyoglobin0.7901.9391.5062.03E-042
P68082MBMyoglobin0.7101.9701.5335.12E-042
P04406GAPDHGlyceraldehyde-3-phosphate dehydrogenase0.1410.7290.7292.22E-022
P60174TPI1Triosephosphate isomerase0.3451.0670.8938.03E-042
P60174–4TPI1Isoform 4 of Triosephosphate isomerase0.3271.1100.9231.17E-032
P63104YWHAZ14–3-3 protein zeta/delta0.2410.4330.4588.41E-032
P31946–2YWHABIsoform Short of 14–3-3 protein beta/alpha0.1570.3880.3133.94E-032
Q04917YWHAH14–3-3 protein eta0.1950.4220.4831.52E-032
P27348YWHAQ14–3-3 protein theta0.1560.3680.3949.83E-042
P31947SFN14–3-3 protein sigma0.1910.4270.5423.55E-042
P28838LAP3Cytosol aminopeptidase0.1660.5620.6332.12E-022
E7EQ12CASTCalpastatin0.1530.4340.5542.26E-032
P15259PGAM2Phosphoglycerate mutase 20.2941.1571.3882.08E-042
P61158ACTR3Actin-related protein 30.1540.2480.2551.66E-022
P05413FABP3Fatty acid-binding protein, heart0.6151.8311.8511.13E-042
P40926MDH2Malate dehydrogenase, mitochondrial0.7471.9761.3741.21E-042
Q5JRA6MIA3Melanoma inhibitory activity protein 30.3080.5060.4436.73E-042
P23526AHCYAdenosylhomocysteinase0.1820.4770.4351.93E-032
P15121AKR1B1Aldose reductase0.2761.0090.7788.03E-042
P35237SERPINB6Serpin B60.0500.2250.2041.08E-022
Q5T4U5ACADMAcyl-Coenzyme A dehydrogenase, C-4 to C-12 straight chain, isoform CRA a0.4521.1381.2591.17E-032
O15143ARPC1BActin-related protein 2/3 complex subunit 1B0.1450.2910.2623.00E-022
P07738BPGMBisphosphoglycerate mutase0.1360.3370.3272.26E-022
Q9HC38–2GLOD4Isoform 2 of Glyoxalase domain-containing protein 40.0590.3230.3422.86E-022
Q9HC38GLOD4Glyoxalase domain-containing protein 40.0590.3370.3423.19E-022
B7Z403GLOD4Glyoxalase domain-containing protein 40.0660.3240.3293.00E-022
P61160ACTR2Actin-related protein 20.1490.2480.2762.15E-022
P10768ESDS-formylglutathione hydrolase0.1410.5500.6101.23E-032
Q8N142ADSSL1Adenylosuccinate synthetase isozyme 10.1251.0541.0381.72E-022
Q9UJ70NAGKN-acetyl-d-glucosamine kinase0.0480.2610.2022.65E-022
P54727RAD23BUV excision repair protein RAD23 homolog B0.1020.2990.3892.26E-032
P30086PEBP1Phosphatidylethanolamine-binding protein 10.2560.8770.5535.07E-032
Q99497PARK7Protein DJ-10.0590.4390.5114.01E-032
Q13011ECH1Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial0.3001.4331.1861.99E-032
P00492HPRT1Hypoxanthine-guanine phosphoribosyltransferase0.1230.3550.3651.06E-032
Q32Q12NME1-NME2Nucleoside diphosphate kinase0.1120.4470.3052.81E-032
P15531–2NME1Isoform 2 of Nucleoside diphosphate kinase A0.1140.4300.3592.75E-032
F6XY72NME1-NME2Protein NME1-NME20.0780.4560.2691.53E-032
Q9UL46PSME2Proteasome activator complex subunit 20.1060.3160.3424.57E-022
Q16836–2HADHIsoform 2 of Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial0.5421.8981.4852.03E-042
Q13642–4FHL1Isoform 4 of Four and a half LIM domains protein 10.2350.8410.6421.98E-042
P62805HIST1H4AHistone H40.6311.1661.4417.14E-052
Q8TDQ7GNPDA2Glucosamine-6-phosphate isomerase 20.0970.2340.2911.57E-022
P46926GNPDA1Glucosamine-6-phosphate isomerase 10.1540.4170.4454.17E-032
Q96DG6CMBLCarboxymethylenebutenolidase homolog0.1600.8330.7492.21E-022
P59998ARPC4Actin-related protein 2/3 complex subunit 40.1750.4150.3502.12E-022
P00441SOD1Superoxide dismutase [Cu-Zn]0.1680.6290.4482.12E-022
P49247RPIARibose-5-phosphate isomerase0.0710.2150.2002.04E-022
P02689PMP2Myelin P2 protein0.2960.8220.8241.98E-022
Q96C23GALMAldose 1-epimerase0.0470.3810.4724.08E-022
P29218IMPA1Inositol monophosphatase 10.1740.6790.8748.74E-042
P30042C21orf33ES1 protein homolog, mitochondrial0.4091.3301.2481.11E-032
Q15631TSNTranslin0.1640.3340.3675.07E-032
O00764PDXKPyridoxal kinase0.1130.8000.7802.49E-022
P63208SKP1S-phase kinase-associated protein 10.0950.4340.3522.38E-022
O15145ARPC3Actin-related protein 2/3 complex subunit 30.1600.3500.3262.36E-022
Q04760GLO1Lactoylglutathione lyase0.2870.7420.5232.29E-032
P06734FCER2Low affinity immunoglobulin epsilon Fc receptor0.1300.1840.1884.45E-022
P07108DBIAcyl-CoA-binding protein0.2210.6880.5231.18E-022
P50461CSRP3Cysteine and glycine-rich protein 30.3591.5041.6175.93E-052
U3KQK0HIST1H2BNHistone H2B0.5221.2511.5562.06E-052
P33778HIST1H2BBHistone H2B type 1-B0.5821.2591.6064.41E-052
Q99880HIST1H2BLHistone H2B type 1-L0.5361.2691.5732.06E-052
P30048PRDX3Thioredoxin-dependent peroxide reductase, mitochondrial0.0850.8821.0137.43E-032
O95861–2BPNT1Isoform 2 of 3′(2′),5′-bisphosphate nucleotidase 10.0920.4780.4581.41E-032
O75347TBCATubulin-specific chaperone A0.0200.2960.2614.86E-022
P84243H3F3AHistone H3.30.5841.2411.5022.03E-042
P68431HIST1H3AHistone H3.10.5701.1811.4115.93E-052
Q71DI3HIST2H3AHistone H3.20.6481.2561.5062.08E-042
Q5TEC6HIST2H3PS2Histone H30.4671.0841.3227.20E-042
P10644PRKAR1AcAMP-dependent protein kinase type I-alpha regulatory subunit0.1050.3110.3212.12E-022
Q9NR45NANSSialic acid synthase0.1060.3120.3881.61E-022
Q9H0R4HDHD2Haloacid dehalogenase-like hydrolase domain-containing protein 20.1790.6190.7735.11E-032
P61970NUTF2Nuclear transport factor 20.0440.3430.2183.53E-022
Q9NVS9PNPOPyridoxine-5′-phosphate oxidase0.1820.4070.4193.45E-022
Q12765–2SCRN1Isoform 2 of Secernin-10.0920.2340.2822.63E-022
Q6FI13HIST2H2AA3Histone H2A type 2-A0.6651.4831.8433.17E-042
Q7L7L0HIST3H2AHistone H2A type 30.6671.4971.8432.99E-042
P0C0S5H2AFZHistone H2A.Z0.7991.5221.9342.79E-032
P23297S100A1Protein S100-A10.9771.6781.9676.15E-042
O15511ARPC5Actin-related protein 2/3 complex subunit 50.2090.2830.3242.76E-022
P35754GLRXGlutaredoxin-10.0400.3160.2792.24E-032
Q9NRX4PHPT114 kDa phosphohistidine phosphatase0.1440.4500.2961.66E-022
Q99729HNRNPABHeterogeneous nuclear ribonucleoprotein A/B0.1170.2400.2643.18E-022
Q14061COX17Cytochrome c oxidase copper chaperone0.8581.7121.3422.08E-042
Q7Z4H3HDDC2HD domain-containing protein 20.0890.5690.5182.51E-032
Q99471PFDN5Prefoldin subunit 50.2650.6050.5004.92E-032
P14621ACYP2Acylphosphatase-20.1980.6960.6078.97E-032
U3KQL2ACYP2Acylphosphatase-20.2120.5700.5207.64E-032
Q07507DPTDermatopontin0.4540.7490.6542.27E-022
B7Z4W5CCBL1Cysteine conjugate-beta lyase cytoplasmic (Glutamine transaminase K, kyneurenine aminotransferase), isoform CRA b−0.0370.6870.8103.24E-022
Q9UHP9SMPXSmall muscular protein0.4640.6430.6599.28E-032
P07919UQCRHCytochrome b-c1 complex subunit 6, mitochondrial0.6741.8971.6529.22E-032
P49789FHITBis(5′-adenosyl)-triphosphatase0.0501.0260.6082.49E-022
Q0VDG4SCRN3Secernin-30.2460.4330.5662.79E-032
Q86YS3RAB11FIP4Rab11 family-interacting protein 40.2080.8110.6529.67E-032
Q9ULP9TBC1D24TBC1 domain family member 240.0600.6020.7225.95E-032
Q9BPX5ARPC5LActin-related protein 2/3 complex subunit 5-like protein0.1850.5590.5552.22E-022
O14561NDUFAB1Acyl carrier protein, mitochondrial0.2981.0981.3483.93E-032
O75369–8FLNBIsoform 8 of Filamin-B0.2270.3280.2851.01E-033
Q00610CLTCClathrin heavy chain 10.3080.4410.2284.08E-023
J3KN67TPM3Tropomyosin alpha-3 chain0.4570.5200.3224.52E-023
P06753–6TPM3Isoform 6 of Tropomyosin alpha-3 chain0.4690.5240.3133.96E-023
P06753–5TPM3Isoform 5 of Tropomyosin alpha-3 chain0.4720.5260.3064.24E-023
P48735IDH2Isocitrate dehydrogenase [NADP], mitochondrial0.8742.0550.9782.16E-043
P08670VIMVimentin0.2610.3560.2364.92E-033
P07196NEFLNeurofilament light polypeptide0.2030.3240.2462.50E-023
Q96G03PGM2Phosphoglucomutase-20.1210.3580.0783.00E-023
Q06830PRDX1Peroxiredoxin-10.1450.4200.2584.56E-023
B1AVU8PSAPSaposin-D0.1620.1910.0945.99E-033
P07602–3PSAPIsoform Sap-mu-9 of Prosaposin0.1640.2120.0955.11E-033
P21709EPHA1Ephrin type-A receptor 10.1820.2770.1214.30E-023
Q16555DPYSL2Dihydropyrimidinase-related protein 20.1040.1810.0754.27E-023
Q14194–2CRMP1Isoform LCRMP-1 of Dihydropyrimidinase-related protein 10.1510.2770.1253.45E-023
P23284PPIBPeptidyl-prolyl cis-trans isomerase B0.1650.2700.1473.14E-023
P08590MYL3Myosin light chain 31.1981.5100.8431.81E-043
P12829MYL4Myosin light chain 41.0621.2850.5337.30E-033
P07585DCNDecorin0.5560.7600.4562.03E-043
P62937PPIAPeptidyl-prolyl cis-trans isomerase A0.1030.3610.1673.55E-033
P62937–2PPIAIsoform 2 of Peptidyl-prolyl cis-trans isomerase A0.0890.3440.1457.81E-033
Q9Y625GPC6Glypican-60.2170.3650.2107.29E-033
P21810BGNBiglycan0.7150.8870.4582.16E-043
P62158CALM1Calmodulin0.2310.4350.1617.64E-033
P09211GSTP1Glutathione S-transferase P0.0890.3630.1691.58E-023
P19338NCLNucleolin0.2810.4810.3802.21E-023
Q9BRF8CPPED1Serine/threonine-protein phosphatase CPPED10.2150.5180.3057.44E-033
P03950ANGAngiogenin0.1660.3180.1663.53E-023
Q9UBQ0VPS29Vacuolar protein sorting-associated protein 290.2030.5030.2432.67E-023
P12104FABP2Fatty acid-binding protein, intestinal0.2650.4380.0929.69E-033
Q9NQ30ESM1Endothelial cell-specific molecule 10.7050.9560.7472.08E-043
P50897PPT1Palmitoyl-protein thioesterase 10.1530.3730.0884.45E-033
P36543ATP6V1E1V-type proton ATPase subunit E 10.2240.2690.2452.71E-023
P30405PPIFPeptidyl-prolyl cis-trans isomerase F, mitochondrial0.6441.6100.6124.01E-033
P20674COX5ACytochrome c oxidase subunit 5A, mitochondrial1.0361.5340.5941.11E-023
Q09028RBBP4Histone-binding protein RBBP40.3170.6710.3154.27E-023
P02585TNNC2Troponin C, skeletal muscle0.5190.6070.2742.12E-023
O43447PPIHPeptidyl-prolyl cis-trans isomerase H0.1250.3590.1952.12E-023
Q96G01BICD1Protein bicaudal D homolog 10.3320.4270.3312.65E-023
O75380NDUFS6NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial0.3771.0660.6562.12E-023
P18206VCLVinculin0.1020.2110.4381.88E-034
P26038MSNMoesin0.0650.1680.2641.26E-024
P15311EZREzrin0.0260.2030.4431.11E-024
P35241–5RDXIsoform 5 of Radixin0.0700.2530.4197.64E-034
P11216PYGBGlycogen phosphorylase, brain form0.1330.4690.7914.01E-034
P34932HSPA4Heat shock 70 kDa protein 40.0390.1260.2971.02E-024
P11142HSPA8Heat shock cognate 71 kDa protein0.1110.4190.7292.58E-044
P08107HSPA1AHeat shock 70 kDa protein 1A/1B0.0950.4440.7606.71E-044
P17066HSPA6Heat shock 70 kDa protein 60.1380.5590.8852.45E-044
P14618–2PKMIsoform M1 of Pyruvate kinase PKM0.0750.4010.9102.03E-044
P14618PKMPyruvate kinase PKM0.0770.3810.8802.32E-044
P06732CKMCreatine kinase M-type0.2601.1081.8275.93E-054
P12277CKBCreatine kinase B-type0.2731.1131.7605.93E-054
P31150GDI1Rab GDP dissociation inhibitor alpha0.0650.1590.2577.26E-034
P04075–2ALDOAIsoform 2 of Fructose-bisphosphate aldolase A−0.0150.2040.5474.89E-044
P09972ALDOCFructose-bisphosphate aldolase C−0.0190.1280.5275.42E-034
P36871PGM1Phosphoglucomutase-10.0860.5811.1398.28E-044
P06744GPIGlucose-6-phosphate isomerase0.2210.8591.3314.88E-044
P00338LDHAl-lactate dehydrogenase A chain0.0750.1920.3832.21E-024
P07195LDHBl-lactate dehydrogenase B chain0.0510.2430.6947.48E-044
P07864LDHCl-lactate dehydrogenase C chain0.0870.2990.6391.60E-034
P52209PGD6-phosphogluconate dehydrogenase, decarboxylating0.0830.2690.3851.78E-024
Q6ZN40TPM1Tropomyosin 1 (Alpha), isoform CRA f0.3210.6420.9402.57E-044
H0YK48TPM1Tropomyosin alpha-1 chain0.3250.6140.8921.93E-034
P09493–4TPM1Isoform 4 of Tropomyosin alpha-1 chain0.3130.6160.8941.78E-034
P55786NPEPPSPuromycin-sensitive aminopeptidase0.1090.2810.5532.08E-044
P55786–2NPEPPSIsoform 2 of Puromycin-sensitive aminopeptidase0.1070.2780.5572.16E-044
A2A274ACO2Aconitate hydratase, mitochondrial0.0210.4971.3642.79E-034
P13929ENO3Beta-enolase0.1730.6410.9742.43E-034
P09104ENO2Gamma-enolase0.1110.3000.5026.15E-044
P17174GOT1Aspartate aminotransferase, cytoplasmic−0.0120.5591.3305.12E-044
P02545LMNAPrelamin-A/C0.0960.2540.4103.43E-024
P62258YWHAE14–3-3 protein epsilon0.1830.5040.7515.12E-044
P61981YWHAG14–3-3 protein gamma0.1610.4550.7222.16E-044
P40925–3MDH1Isoform 3 of Malate dehydrogenase, cytoplasmic0.1011.0451.8231.14E-044
P78417GSTO1Glutathione S-transferase omega-10.0710.2760.5101.09E-024
P20810–6CASTIsoform 6 of Calpastatin0.1230.4010.5503.24E-034
P09622DLDDihydrolipoyl dehydrogenase, mitochondrial0.1080.5520.9197.57E-034
P42765ACAA23-ketoacyl-CoA thiolase, mitochondrial0.0620.5170.9382.88E-024
P18669PGAM1Phosphoglycerate mutase 10.1620.7101.0021.27E-034
P17540CKMT2Creatine kinase S-type, mitochondrial0.3661.1051.5681.11E-044
Q16881–5TXNRD1Isoform 5 of Thioredoxin reductase 1, cytoplasmic0.0390.1630.2801.33E-024
Q16881–3TXNRD1Isoform 3 of Thioredoxin reductase 1, cytoplasmic0.0390.1640.2781.20E-024
P99999CYCSCytochrome c0.0580.9641.7802.16E-044
Q15124PGM5Phosphoglucomutase-like protein 50.2510.9081.3691.11E-044
P31153MAT2AS-adenosylmethionine synthase isoform type-20.0550.1880.4603.64E-024
P11766ADH5Alcohol dehydrogenase class-30.0800.6661.1272.08E-044
P25786–2PSMA1Isoform Long of Proteasome subunit alpha type-10.0560.2600.4503.91E-024
P16083NQO2Ribosyldihydronicotinamide dehydrogenase [quinone]0.0510.2290.4593.35E-024
O14818PSMA7Proteasome subunit alpha type-70.1050.1970.4003.19E-024
P21266GSTM3Glutathione S-transferase Mu 30.1200.3550.6173.32E-044
P28161GSTM2Glutathione S-transferase Mu 20.0840.4190.7344.47E-034
E9PHN7GSTM2Glutathione S-transferase Mu 20.0940.4040.7365.74E-034
P09488GSTM1Glutathione S-transferase Mu 10.1260.3350.6791.01E-024
Q03013GSTM4Glutathione S-transferase Mu 40.1120.3280.6681.06E-024
Q96CN7ISOC1Isochorismatase domain-containing protein 10.0260.2500.7178.16E-034
Q9NQW7–3XPNPEP1Isoform 3 of Xaa-Pro aminopeptidase 10.0420.1660.3903.62E-034
P49721PSMB2Proteasome subunit beta type-20.0700.2630.4032.43E-024
P46940IQGAP1Ras GTPase-activating-like protein IQGAP10.0680.0480.3233.37E-024
P25789PSMA4Proteasome subunit alpha type-40.0840.2650.5083.49E-024
H0YLC2PSMA4Proteasome subunit alpha type0.0800.2700.5054.04E-024
P62140PPP1CBSerine/threonine-protein phosphatase PP1-beta catalytic subunit0.0960.2270.3353.31E-034
P62136PPP1CASerine/threonine-protein phosphatase PP1-alpha catalytic subunit0.0890.1880.3111.12E-024
P36873–2PPP1CCIsoform Gamma-2 of Serine/threonine-protein phosphatase PP1-gamma catalytic subunit0.0850.2040.3108.50E-034
P55809OXCT1Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial0.0230.1060.8122.61E-034
P09417QDPRDihydropteridine reductase0.0400.3110.6311.57E-024
Q9ULA0DNPEPAspartyl aminopeptidase0.0720.3080.5623.17E-044
E7ETB3DNPEPAspartyl aminopeptidase0.0660.3110.5773.89E-044
P28074PSMB5Proteasome subunit beta type-5−0.0310.1570.3724.54E-024
Q9NZL9MAT2BMethionine adenosyltransferase 2 subunit beta0.0670.1140.3862.88E-024
P41250GARSGlycine–tRNA ligase0.0530.1790.3022.49E-024
P55083–2MFAP4Isoform 2 of Microfibril-associated glycoprotein 40.1110.2150.3501.56E-024
Q5JSH3WDR44WD repeat-containing protein 440.0620.1510.2843.70E-024
Q8NCW5APOA1BPNAD(P)H-hydrate epimerase0.0440.2900.6421.56E-034
Q9Y3B8–3REXO2Isoform 3 of Oligoribonuclease, mitochondrial0.0460.7000.9402.42E-034
P30046DDTd-dopachrome decarboxylase0.0740.4260.6954.26E-024
Q8IW45CARKDATP-dependent (S)-NAD(P)H-hydrate dehydratase0.0300.3400.6453.78E-024
P53041PPP5CSerine/threonine-protein phosphatase 50.1160.3230.6731.97E-034
P26022PTX3Pentraxin-related protein PTX30.1220.5010.7624.79E-044
P34949MPIMannose-6-phosphate isomerase0.1880.3450.6625.52E-044
Q06124PTPN11Tyrosine-protein phosphatase non-receptor type 11−0.0470.1430.2973.00E-024
Q96HC4–6PDLIM5Isoform 6 of PDZ and LIM domain protein 50.0900.3400.5182.65E-024
Q96HC4PDLIM5PDZ and LIM domain protein 50.1160.2450.4194.08E-024
O75390CSCitrate synthase, mitochondrial0.0040.3251.4565.12E-044
P61457PCBD1Pterin-4-alpha-carbinolamine dehydratase0.1560.4081.0441.71E-024
P28070PSMB4Proteasome subunit beta type-40.1380.2130.3646.68E-034
J3QL71SCRN2Secernin-20.0360.1460.3271.66E-024
O95817BAG3BAG family molecular chaperone regulator 30.1180.3460.5131.45E-024
P45379TNNT2Troponin T, cardiac muscle−0.0670.4321.7435.07E-034
K7ER74APOC4-APOC2Protein APOC4-APOC2−0.879−0.5740.4951.56E-034
P55056APOC4Apolipoprotein C-IV−0.517−0.2310.3364.73E-024
P61601NCALDNeurocalcin-delta0.0280.1810.2413.17E-024
P63316TNNC1Troponin C, slow skeletal and cardiac muscles0.3200.3701.3132.19E-034
Q6ICJ4Em:AP000351.3Em:AP000351.3 protein−0.0620.3980.8934.61E-024
O75367H2AFYCore histone macro-H2A.10.2200.3540.7113.44E-024
O75112LDB3LIM domain-binding protein 30.0350.2690.6161.94E-024
Q96GD0PDXPPyridoxal phosphate phosphatase0.1440.1710.3632.81E-024
Q99598TSNAXTranslin-associated protein X0.1290.2000.3624.27E-024
P46976GYG1Glycogenin-1−0.0360.4400.7242.42E-024
Q8WZA9IRGQImmunity-related GTPase family Q protein0.1010.1870.5403.00E-024
P49748–3ACADVLIsoform 3 of Very long-chain specific acyl-CoA dehydrogenase, mitochondrial−0.1560.8742.1591.69E-024
Q14896MYBPC3Myosin-binding protein C, cardiac-type−0.0920.1400.7194.59E-024
P38646HSPA9Stress-70 protein, mitochondrial0.1090.5070.8216.15E-044
P19429TNNI3Troponin I, cardiac muscle−0.1890.2651.7252.19E-024
P22888LHCGRLutropin-choriogonadotropic hormone receptor0.0770.6421.1241.21E-024
Q5TZA2CROCCRootletin−0.0220.1590.6231.67E-024
Q5TZA2–2CROCCIsoform 2 of Rootletin−0.0480.1700.6341.12E-024
Q13356–2PPIL2Isoform 2 of Peptidyl-prolyl cis-trans isomerase-like 20.0370.1140.5563.72E-024
Q9H7B2RPF2Ribosome production factor 2 homolog0.5000.2471.0913.19E-024
Q07954LRP1Prolow-density lipoprotein receptor-related protein 1−0.120−0.155−0.1613.00E-025
P04114APOBApolipoprotein B-100−0.537−0.583−0.0712.35E-025
P01009SERPINA1Alpha-1-antitrypsin−0.583−0.591−0.1934.61E-025
P49747COMPCartilage oligomeric matrix protein−0.084−0.101−0.1814.57E-025
P03952KLKB1Plasma kallikrein−0.555−0.618−0.6603.29E-025
P01871IGHMIg mu chain C region−0.185−0.195−0.0622.34E-025
P04220Ig mu heavy chain disease protein−0.181−0.177−0.0591.72E-025
Q12805EFEMP1EGF-containing fibulin-like extracellular matrix protein 1−0.410−0.393−0.4571.39E-025
Q12805–5EFEMP1Isoform 5 of EGF-containing fibulin-like extracellular matrix protein 1−0.416−0.415−0.4601.63E-025
O75197LRP5Low-density lipoprotein receptor-related protein 5−0.157−0.231−0.2043.91E-025
P04083ANXA1Annexin A1−0.349−0.348−0.3351.11E-035
Q86U17SERPINA11Serpin A11−0.215−0.160−0.3502.28E-025
P18428LBPLipopolysaccharide-binding protein−0.348−0.504−0.4763.13E-025
Q96CX2KCTD12BTB/POZ domain-containing protein KCTD12−0.076−0.116−0.2743.18E-025
Q9BXD5NPLN-acetylneuraminate lyase−0.144−0.286−0.2791.37E-025
Q6V0I7FAT4Protocadherin Fat 4−0.106−0.231−0.2364.32E-025
P14222PRF1Perforin-1−0.130−0.182−0.2481.88E-035
O15240VGFNeurosecretory protein VGF−0.119−0.325−0.1744.45E-025
Q96MU8–2KREMEN1Isoform 2 of Kremen protein 1−0.209−0.246−0.1937.30E-035
P09525ANXA4Annexin A4−0.330−0.442−0.0941.02E-025
P08236GUSBBeta-glucuronidase−0.421−0.437−0.1991.86E-025
B0YIW2APOC3Apolipoprotein C-III−1.089−1.115−0.4051.74E-025
Q5SPY9NPDC1Neural proliferation differentiation and control protein 1−0.111−0.263−0.2985.67E-035
P04211Ig lambda chain V region 4A−1.026−0.813−0.7301.71E-025
Q92794KAT6AHistone acetyltransferase KAT6A−0.490−0.595−0.0473.68E-025
Q8N201INTS1Integrator complex subunit 1−0.254−0.328−0.3141.02E-025
Q2WGJ9FER1L6Fer-1-like protein 6−0.474−0.314−0.1242.65E-025
P54707–2ATP12AIsoform 2 of Potassium-transporting ATPase alpha chain 2−0.253−0.424−0.2528.50E-035
Q5VT52RPRD2Regulation of nuclear pre-mRNA domain-containing protein 2−0.430−0.601−0.4341.76E-035
Q9UNN5FAF1FAS-associated factor 1−0.882−0.640−0.2301.21E-025
Q8TE49–2OTUD7AIsoform 2 of OTU domain-containing protein 7A−1.744−1.530−1.2173.78E-035
O15072ADAMTS3A disintegrin and metalloproteinase with thrombospondin motifs 3−0.110−0.098−0.4872.04E-025
Q6B0I6KDM4DLysine-specific demethylase 4D−1.120−0.693−0.5514.60E-025
Q9NUL3STAU2Double-stranded RNA-binding protein Staufen homolog 2−0.232−0.548−0.5742.08E-025
J3KPX5DNA2DNA replication ATP-dependent helicase/nuclease DNA2−0.266−0.167−0.1094.91E-025
Q6P2E9EDC4Enhancer of mRNA-decapping protein 4−0.318−0.410−0.0653.64E-025
Q15761NPY5RNeuropeptide Y receptor type 5−0.191−0.544−0.5314.66E-025
Q9Y6Y0IVNS1ABPInfluenza virus NS1A-binding protein−0.116−0.356−0.1044.48E-025
P09493–6TPM1Isoform 6 of Tropomyosin alpha-1 chain0.3350.6350.9066.15E-04NA
E7EVY3CASTCalpastatin0.1290.4050.5364.11E-03NA
Q99983OMDOsteomodulin0.0670.1390.1961.15E-02NA
Q9Y5Z4HEBP2Heme-binding protein 20.1100.4810.2774.26E-02NA
P49354FNTAProtein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha0.0440.2550.3302.71E-02NA
P31040SDHASuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial0.0931.0561.3119.41E-03NA
P61224RAP1BRas-related protein Rap-1b0.2940.3610.3632.96E-02NA
P14174MIFMacrophage migration inhibitory factor0.2650.7790.4993.94E-03NA
Q15843NEDD8NEDD80.0390.2000.2582.79E-03NA
O94913PCF11Pre-mRNA cleavage complex 2 protein Pcf110.2090.1410.2102.61E-03NA
  • a Benjamini-Hochberg corrected p values are reported.

  • b 323 out of 333 regulated proteins were clustered into 5 distinct clusters using Fuzzy C-means clustering. Proteins were assigned into clusters using membership value of > 0.7. Proteins with a membership value in between 0.5 and 0.7 weren't assigned to any cluster and marked as NA.