Table I Clinical characteristics of the patient cohort for biomarker discovery. For categorical and numerical variables, p values were calculated using Fisher's exact test and Kruskal-Wallis test respectively
VariablesHealthyBEEACp value (Healthy vs BE vs EAC)
Sample size91010
Age (Median ± S.D.)66 ± 1062 ± 1566 ± 80.9311
GenderAll maleAll maleAll male
Protein concentration (μg/μl)95 ± 1985 ± 1382 ± 130.3641
Gastritisa1 (11.1%)1 (11.1%)1 (10.0%)1.0000
Peptic ulcer3 (33.3%)2 (20.0%)3 (30.0%)0.8792
Hiatus hernia0 (0.0%)4 (40.0%)6 (60.0%)0.0217
Other malignancy1 (11.1%)2 (20.0%)2 (20.0%)1.0000
  • a All the analyses were performed based on available patient information. Gastritis status for one BE patient was missing.