Table IV List of proteins that were found to be differentially regulated in transgenic mouse model of AD (Tg AD) and in human AD brain (AD).
ModelProteinGeneSign change Tg ADReference in Tg ADSign change ADReference AD brain humanFunction
3xTG ADTriose phosphate isomeraseTPI(98)(98)+(131)Metabolism
(148) (+)(148)
3xTG AD; J20 tg; APPE693deltaAlpha-enolaseENO13x TG AD, APPE693delta (-) /J20 tg (+)(98,103,148,150)+(74,131)Metabolism
TG2576; 3xTG ADNADH dehydrogenase subunitsNDUF-(97,99)-(37)Metabolism
TG2576Cytochrome ccytC-(97)-(74)Metabolism
3xTG AD; Thy1-APP751Dihydropyrimidinase-related protein 2DPYSL23xTG AD (-), Thy1-APP751 (+)(98,147)+(74)Adaptor protein, cytoskeleton regulation, and axonal growth transport
3xTG ADNeurofilament medium polypeptideNEFM-(98)-(83,151)Involved in the maintenance of neuronal caliber
3xTG AD; J20 tgRho GDP-dissociation inhibitor 1ARHGDIA3x TG AD (-) /J20 tg (+)(98,103)-(74)Controls function of Rho family of GTPases
3xTG ADUbiquitin carboxy-terminal hydrolase 1UCHL1-(98)+(152)Regulates levels of ubiquitin
J20 tg; APP/PS1 Human Double Mutant Knock-in MicePeptidyl-prolyl cis-trans isomerasePin-1J20 tg (+) /APP/PS-1 (-)(102,103)(131) (-); (83) and (151) (+)(74,83,131)Regulates mitosis. Acts as a regulator of JNK cascade
3xTG AD; Tau (NSE/htau23); APP/PSEN1 Human Double Mutant Knock-in MiceGlyceraldehyde-3-Phosphate DehydrogenaseGAPDH3xTG AD (+), APP-PS-1 (-)(102,148)+(74)Metabolism
Thy1-APP751 (Tg)Glial fibrillary acidic proteinGFAP+(147)+(74)A class-III intermediate filament
Thy1-APP751 (Tg)Peroxiredoxin-6PRDX6+(147)+(74)Involved in redox regulation of the cell
Thy1-APP751 (Tg)Serum albumin precursorALB+(147)+(74)The main protein of plasma
APPE693deltaNeurofilament light polypeptideNEFL-(125)-(151)Cytoskeleton
APP/PSEN1 Human Double Mutant Knock-in MiceFructose-bisphosphate aldolase CALDOC-(102)+(74)Metabolism
APP/PS-1 Human Double Mutant Knock-in MiceHeat shock protein 90αHSP90AA1-(102)-(74)Molecular chaperone
3xTG ADSuperoxide dismutaseSOD1+(148)+(83)Antioxidant defense
3xTG ADTubulin polymerization promoting proteinTPPP+(148)(74) (+); (151) (-)(74,151)Tubulin polymerization
3xTG AD14-3-3 protein beta/alphaYWHAB+(148)-(74)Scafold protein