Table I Chinchilla proteins that exhibited significant changes in amount due to NTHI-induced AOM (* Amino acid identity to human orthologue)
Protein accession no.FunctionFold change of infected/shamIdentity (%)*
XP_005375096.1neutrophil cytosol factor 2 isoform X213.288.7
XP_005379227.1neutrophil cytosol factor 46.289.1
XP_005414659.1protein S100-A86.273.6
XP_005409872.1protein-arginine deiminase type-44.378.5
XP_005396685.1uridine phosphorylase 1 isoform X44.178.8
XP_005415265.1lysozyme C-like4.084.8
XP_005393368.1grancalcin isoform X13.768.6
XP_005378904.1tyrosine-protein phosphatase non-receptor type 6 isoform X13.694.3
XP_005414660.1protein S100-A93.565.1
XP_005383459.115 kDa protein A-like3.431.7
XP_005379226.1parvalbumin alpha3.389.1
XP_005415392.1aldehyde dehydrogenase 13.391.2
XP_005382437.1neutrophil gelatinase-associated lipocalin-like3.262.0
XP_005413882.1peptidoglycan recognition protein 13.271.7
XP_005377232.1polyserase-2-like3.168.3
XP_005389257.1arginase-1 isoform X13.031.0
XP_005406075.1neutrophil elastase3.072.3
XP_005399838.1glia maturation factor gamma isoform X12.995.7
XP_005373598.1high mobility group protein B22.898.1
XP_005412491.1CD177 antigen isoform X12.852.7
XP_005413091.1actin-related protein 2/3 complex subunit 42.8100.0
XP_005383500.1lactotransferrin2.772.8
XP_005375305.1chitotriosidase-1 isoform X12.677.5
XP_005380964.1destrin2.6100.0
XP_005401229.1uncharacterized protein2.694.7
XP_005409156.1plastin-22.697.8
XP_005413229.1uncharacterized protein2.668.2
XP_005385769.1UTP–glucose-1-phosphate uridylyltransferase isoform X42.599.4
XP_005397993.1actin-related protein 2/3 complex subunit 1B isoform X32.598.1
XP_005407657.1phosphoglycerate mutase 12.599.2
XP_005408382.1annexin A12.592.2
XP_005414274.1glucose-6-phosphate 1-dehydrogenase isoform X12.589.4
XP_005394087.1myeloperoxidase2.489.0
XP_005388036.1sorcin isoform X22.393.8
XP_005405241.1coronin-1A2.395.4
XP_005408368.1osteoclast-stimulating factor 12.397.1
XP_005414592.1protein S100-A11 isoform X22.285.2
XP_005374269.1olfactomedin-42.182.2
XP_005378835.1glyceraldehyde-3-phosphate dehydrogenase2.195.8
XP_005381261.1thrombospondin-12.196.3
XP_005388181.1F-actin-capping protein subunit alpha−22.197.8
XP_005404076.16-phosphogluconate dehydrogenase, decarboxylating2.194.2
XP_005409388.1lamin-B1 isoform X12.197.9
XP_005408993.1metalloproteinase inhibitor 1 isoform X22.075.6
XP_005379277.1galectin-1 isoform X4−2.085.2
XP_005377495.1heterogeneous nuclear ribonucleoproteins A2/B1 isoform X5−2.1100.0
XP_005386842.1annexin A5 isoform X1−2.192.8
XP_005393859.1tropomyosin alpha-4 chain isoform X8−2.199.2
XP_005405252.1fructose-bisphosphate aldolase A isoform X4−2.198.4
XP_005373090.1serpin B4−2.262.3
XP_005384889.1adenosylhomocysteinase−2.296.1
XP_005389440.1N(G),N(G)-dimethylarginine dimethylaminohydrol−2.296.5
XP_005394874.1chloride intracellular channel protein 4−2.298.8
XP_005406050.1ATP synthase subunit delta, mitochondrial isoform X2−2.289.9
XP_005406262.1hydroxyacyl-coenzyme A dehydrogenase, mitochondrial isoform X2−2.289.8
XP_005373784.1dihydropyrimidinase-related protein 2 isoform X1−2.398.5
XP_005389984.1adenosine kinase isoform X1−2.393.5
XP_005407967.1glutamate dehydrogenase 1, mitochondrial-like−2.397.6
XP_005412123.1purine nucleoside phosphorylase isoform X2−2.385.4
XP_005402983.1galectin-9-like−2.453.2
XP_005415261.1neuroblast differentiation-associated protein−2.469.0
XP_005374506.1lumican−2.585.2
XP_005377593.1aldose reductase−2.584.5
XP_005381747.1protein disulfide-isomerase A3−2.587.9
XP_005382153.1stress-70 protein, mitochondrial−2.598.1
XP_005386908.1aldo-keto reductase family 1 member C1 homolog−2.581.1
XP_005388949.1glutathione S-transferase Mu 1-like isoform X2−2.584.4
XP_005398907.1thioredoxin domain-containing protein 5−2.590.7
XP_005405560.1non-muscle caldesmon isoform X7−2.589.8
XP_005406092.1basigin isoform X1−2.567.3
XP_005409541.1tropomyosin alpha-4 chain−2.599.0
XP_005374508.1decorin isoform X2−2.691.7
XP_005380133.1hemoglobin subunit beta−2.681.6
XP_005386118.1beta-hexosaminidase subunit beta−2.679.2
XP_005406364.1lambda-crystallin homolog−2.684.7
XP_005414854.1neuroblast differentiation-associated protein−2.659.8
XP_005375324.1prolargin−2.791.4
XP_005406777.1tubulin alpha-1A chain-like−2.7100.0
XP_005388953.1glutathione S-transferase Mu 5-like isoform X1−2.889.3
XP_005393042.1ceruloplasmin isoform X1−2.983.6
XP_005379942.1serpin H1 isoform X2−23.094.7
XP_005405733.1tartrate-resistant acid phosphatase type 5-like isoform X2−23.090.8
XP_005411945.1methyltransferase-like protein 7A−23.084.3
XP_005414575.1selenium-binding protein 1 isoform X2−23.086.4
XP_005388267.1annexin A3 isoform X3; D−23.190.1
XP_005388944.1glutathione S-transferase Mu 2 isoform X2−23.180.3
XP_005408960.1mimecan−23.186.2
XP_005374405.1cysteine and glycine-rich protein 2−23.299.0
XP_005375980.1collagen alpha-1(VI) chain−23.290.2
XP_005392386.1prostacyclin synthase−23.282.9
XP_005399681.1beta-enolase isoform X3−23.299.0
XP_005391729.1hemoglobin subunit alpha-like−23.384.5
XP_005392450.1matrix metalloproteinase-9−23.379.2
XP_005411706.1prelamin-A/C isoform X3−23.397.0
XP_005387798.1arachidonate 5-lipoxygenase-activating protein−23.492.6
XP_005394586.1band 3 anion transport protein isoform X2−23.580.9
XP_005408386.1retinal dehydrogenase 1-like−23.587.3
XP_005373303.1aldehyde oxidase-like−23.878.2
XP_005382035.1carbonic anhydrase 2−4.083.5
XP_005379564.1tetratricopeptide repeat protein 38−4.285.5
XP_005380714.1dihydropyrimidinase-related protein 3 isoform X2−4.697.4
XP_005375783.1carbonyl reductase [NADPH] 1-like−4.787.3
XP_005392735.1beta-actin-like protein 2 isoform X2−4.786.2
XP_005391730.1hemoglobin subunit alpha-like−5.562.0
XP_005383679.140S ribosomal protein SA-like−6.576.1