Table I Staphylococcus aureus virulence factors grouped based on functional classes with UniProt identifier, common protein names, USA300 gene identifiers, and common protein names. These proteins represent three major classes of virulence factors which are highlighted in this study to understand cytotoxicity and other virulence behaviors
Protein classProtein functionUniprot accessionCommon protein IDUSA300 gene IDProtein name
ImmunomodulatorsBind to IgG and prevent opsonizationA0A0H2XJH7SPASAUSA300_0113Immunoglobulin G binding protein A
Bind to IgG and prevent opsonizationQ2FE79SBISAUSA300_2364Immunoglobulin-binding protein sbi
Inhibit chemotaxis of phagocytesQ2FHS7FLRSAUSA300_1053FPRL1 inhibitory protein
Inhibit chemotaxis of phagocytesA0A0H2XIW0EAPSAUSA300_0883Putative surface protein
Complement inactivation/Fibrinogen-binding proteinsA0A0H2XG16CLFASAUSA300_0772Clumping factor A
Complement inactivationQ2FJ77SDRESAUSA300_0548Serine-aspartate repeat-containing protein E
Complement inactivationQ2FG07ISDHSAUSA300_1677Iron-regulated surface determinant protein H
Complement inactivation/Fibrinogen-binding proteinsA0A0H2XH00ECBSAUSA300_1052Fibrinogen-binding protein
Complement inactivation/Fibrinogen-binding proteinsA0A0H2XIH9EFBSAUSA300_1055Fibrinogen-binding protein
Complement inactivationA0A0H2XFS8SAKSAUSA300_1922Staphylokinase
Fibrinogen-binding proteins/Surface-bound adhesinsQ2FE03FNBASAUSA300_2441Fibronectin-binding protein A
Fibrinogen-binding proteins/Surface-bound adhesinsA0A0H2XKG3FNBBSAUSA300_2440Fibronectin binding protein B
Surface-bound adhesinsA0A0H2XHK2CLFBSAUSA300_2565Clumping factor B
Surface-bound adhesinsQ2FJ78SDRDSAUSA300_0547Serine-aspartate repeat-containing protein D
Exo-enzymesProteaseQ2FFS9SPLFSAUSA300_1753Serine protease SplF
ProteaseQ2FFT0SPLESAUSA300_1754Serine protease SplE
ProteaseQ2FFT3SPLDSAUSA300_1755Serine protease SplD
ProteaseQ2FFT1SPLCSAUSA300_1756Serine protease SplC
ProteaseQ2FFT2SPLBSAUSA300_1757Serine protease SplB
ProteaseQ2FFT4SPLASAUSA300_1758Serine protease SplA
ProteaseA0A0H2XGH9SSPBSAUSA300_0950Cysteine protease
ProteaseA0A0H2XDQ5AURSAUSA300_2572Zinc metalloproteinase aureolysin
LipaseA0A0H2XK15PLCSAUSA300_00991-phosphatidylinositol phosphodiesterase
LipaseA0A0H2XI72GEHSAUSA300_0320Triacylglycerol lipase
HyaluronidaseA0A0H2XIY1HYSASAUSA300_2161Hyaluronate lyase
NucleaseA0A0H2XHI2NUCSAUSA300_0776Thermonuclease
CoagulaseA0A0H2XHP9COASAUSA300_0224Staphylocoagulase
CoagulaseA0A0H2XEN7VWBPSAUSA300_0773Putative staphylocoagulase
CytotoxinsLeukocidinsQ2FFA2LUKASAUSA300_1975Uncharacterized leukocidin-like protein 2
LeukocidinsA0A0H2XI46LUKS-PVSAUSA300_1382Panton-Valentine leukocidin, LukS-PV
LeukocidinsA0A0H2XFK0LUKF-PVSAUSA300_1381Panton-Valentine leukocidin, LukF-PV
LeukocidinsQ2FFA3LUKBSAUSA300_1974Uncharacterized leukocidin-like protein 1
Leukocidins/hemolysinsA0A0H2XFN4LUKDSAUSA300_1768Leukotoxin LukD
Leukocidins/hemolysinsA0A0H2XJW6LUKESAUSA300_1769Leukotoxin LukE
LeukocidinsP0C817PSMA4SAUSA300_0424.1Phenol-soluble modulin alpha 1 peptide
LeukocidinsP0C7Y0PSMA2SAUSA300_0424.4Phenol-soluble modulin alpha 2 peptide
HemolysinA0A0H2XEW5HLASAUSA300_1058Alpha-hemolysin
Leukocidins/hemolysinsA0A0H2XIG9hlgASAUSA300_2365Gamma-hemolysin component A
Leukocidins/hemolysinsA0A0H2XH48HLGBSAUSA300_2367Gamma-hemolysin component B
Leukocidins/hemolysinsA0A0H2XFL0HLGCSAUSA300_2366Gamma-hemolysin component C