Table II Descriptive parameters of plasma glycome in children with ASD and controls. Glycan structures present in each glycan peaks (GP1–16, DG1–13) are shown in Supplementary Table I, and the way other glycans traits were calculated is described in the Materials and Methods section. Associations between ASD and N-glycans were calculated using a linear mixed effects model with N-glycans as the criterion and ASD as the predictor (fixed effect). Additionally, sex and age were used as covariates (both fixed effects).
ASDControlsLinear regression with ASD as predictor
NMedianPercentilesNMedianPercentiles
25th75thValid25th75th
Age7811.009.0014.004812.509.2515.75
Glycan featurep
GP1780.060.050.07480.050.040.075.03E-01
GP2782.932.533.43482.552.093.193.76E-01
GP3781.661.551.84481.611.401.826.39E-02
GP4785.504.895.95485.214.556.037.81E-01
GP5782.342.202.49482.292.132.526.90E-02
GP6784.163.774.48484.273.744.807.22E-01
GP7789.659.1410.35489.579.0310.366.87E-01
GP87810.539.8511.084810.7810.0111.248.88E-01
GP97840.2838.3741.584840.3838.2541.649.87E-01
GP10786.625.817.25486.586.047.025.86E-01
GP11781.621.481.76481.591.411.741.00E+00
GP12781.561.421.66481.561.421.718.71E-01
GP13785.524.976.14485.765.016.626.22E-01
GP14785.384.636.47485.564.936.086.79E-01
GP15780.760.600.87480.770.650.916.05E-01
GP16781.301.161.47481.271.121.495.41E-01
DG1780.070.050.10480.060.040.099.72E-01
DG2783.533.084.20483.252.763.697.49E-01
DG3782.502.282.71482.442.092.691.06E-01
DG4786.485.806.99486.275.216.917.64E-01
DG57851.7150.2053.224851.5250.0453.059.60E-01
DG67814.8013.7516.064814.8813.8415.957.76E-01
DG7781.501.371.71481.541.371.733.38E-01
DG87810.749.9311.954811.0910.1212.337.17E-01
DG9783.032.373.94483.322.693.753.84E-01
DG10780.980.901.06480.980.921.034.64E-01
DG11782.652.292.93482.592.362.989.46E-01
DG12780.760.610.96480.790.690.964.89E-01
DG13780.750.620.91480.770.660.939.63E-01
Monosialo7822.1521.0423.794822.2920.8223.606.27E-01
Disialo7860.1458.9461.344859.9458.7461.116.05E-01
Trisialo7813.5512.6415.064813.7212.6616.076.78E-01
Tetrasialo783.473.104.00483.523.053.891.67E-01
FUC-C7822.2720.4523.944822.5620.8224.058.52E-01
FUC-A782.842.563.28482.882.643.313.38E-01
BAMS7829.7328.2031.214829.7628.5031.046.80E-01
BADS7870.7869.2172.464871.4168.6872.385.99E-01
BA7880.6079.2982.174880.7378.2381.734.32E-01
TRIA7815.1813.9316.284815.1714.4016.963.02E-01
TA784.163.724.65484.273.854.669.95E-01
A2780.070.050.09480.060.040.088.13E-01