Table V

HLA-DR-bound peptides common to patients with the DRB1*0101 allele (RA2 and LA1)

Peptide sequenceaGene symbolNo. IDbSource protein
RA2LA1
SPDRIFFHLNAVALGDGA1BG23α1B-Glycoprotein
DHPTFNKITPNLAEFSERPINA121α1-Antitrypsin
SGKPQYMVLVPSLLHTETA2M3128α2-Macroglobulin
SDTSYVSLKAPLTKPLCRP49C-reactive protein
LINEYWVLTAAHVVEGC1S310C1s complement subcomponent
SGDVFTALIGEIASPNC1S49C1s complement subcomponent
SPMYSIITPNILRLESC31421C3 complement
LVAYYTLIGASGQRC322C3 complement
GPGIPGRFTKEAGTLAYYECHI3L112Cartilage glycoprotein 39
GGGYVKLFPNSLDQTCALR32Calreticulin
TGKLVSLSAQNLVDCTSS22Cathepsin S
TAFQYIIDNKGIDSDACTSS55Cathepsin S
VSGTLVLLQGARGFACD1465CD14 monocyte differentiation antigen
SNVDMDFEVENAVLGKDFKF13A188Coagulation factor XIII A1
GSAGHWTSESSVSGSTGFGA101Fibrinogen α chain
GETSEMYLIQPDSSVKPYRFGB23Fibrinogen β chain
GLLWIALHGNQITSDFMOD13Fibromodulin
DEPQYLDLPSTATSVNFN111Fibronectin
DDDGTGQKQIWRIEGSNKVPVDPAGSN112Gelsolin
TGAQELLRVLRAQPVQVAGSN56Gelsolin
TGDAYVILKTVQLRNGNLGSN1513Gelsolin
KNSLYLQMNSLRAEDTIGHV53Ig heavy chain variable region
KNTLYLQMNSLRVEDTIGHV21Ig heavy chain variable region
KNTLYLQMNSLRAEDTIGHV113Ig heavy chain variable region
APSAILPLPGQSVERLITIH434Inter-α-trypsin inhibitor heavy chain
AISDYVFNTASLVYHEELBP23Lipopolysaccharide-binding protein
LPQPDLRYLFLNGNKLARVALRG166Leucine-rich α-glycoprotein 1
NFEPFFMMIATPAPHGNS45N-Acetylglucosamine-6-sulfatase
QGGQFLRAVAQRCPSPPPPT111Palmitoyl-protein thioesterase 1
SPERPFLAILGGAKVADKPGK142Phosphoglycerate kinase 1
YAGKYVPAIAHLIHSLCPVL2422Probable serine carboxypeptidase
ASHFEQMAAASMHRQSCN612Quiescin Q6
LFEQLGEYKFQNALLVRYTKKALB4244Serum albumin
ANGVIHMLDGILLPPTSTAB186Stabilin-1
VVYYRVQNATLAVANSTOM31Stomatin
KGNQFWAIRGNEVRAGMMP325Stromelysin-1
GPDPSSPAFRIEDANLIPPVPDTHBS117Thrombospondin-1
TAADYKILGGSVLHLNEDD812Ubiquitin like protein NEDD8
  • a Because the identified peptides varied in length, only the longest peptide is shown. Amino acid residues in bold print indicate the TEPITOPE-predicted P1 binding sites for HLA-DRB1*0101. Because multiple binding registers were predicted for many peptides, only the register with the highest likelihood of binding is indicated. Tandem MS/MS spectra obtained for the listed peptides are presented in supplemental material pages 18–55.

  • b Number of times a peptide sequence was identified in the patients' samples.