Table II List of selected candidates potentially affected by PRA1 knockdown
Accession No.Protein nameGene nameGO biological process categoryaProtein level in PRA1-knockdown cells
Lipid transport/metabolism-related
    IPI00007797.3Fatty acid-binding protein, epidermalFABP5lipid metabolic process; epidermis developmentup-regulation
    IPI00008475.1Hydroxymethylglutaryl-CoA synthase, cytoplasmicHMGCS1cholesterol biosynthetic processup-regulation
    IPI00009236.5Isoform Alpha of Caveolin-1CAV1cholesterol homeostasis; cholesterol transpor; endocytosisup-regulation
    IPI00018452.1Copine-1CPNE1lipid metabolic process; vesicle-mediated transportdown-regulation
    IPI00026546.1Platelet-activating factor acetylhydrolase IB subunit betaPAFAH1B2lipid catabolic processup-regulation
    IPI00218918.5Annexin A1ANXA1cell motion; lipid metabolic process; anti-apoptosisup-regulation
    IPI00303882.2Isoform B of Mannose-6-phosphate receptor-binding protein 1TIP47vesicle-mediated transportup-regulation
    IPI00644020.1Sterol O-acyltransferase (Acyl-Coenzyme A: cholesterol acyltransferase) 1SOAT1cholesterol metabolic processdown-regulation
Cell adhesion/migration-related
    IPI00010697.1Isoform Alpha-6X1X2B of Integrin alpha-6 precursorITGA6cell adhesion; integrin-mediated signaling pathwayup-regulation
    IPI00015117.2Isoform Long of Laminin subunit gamma-2 precursorLAMC2cell adhesion; epidermis developmentup-regulation
    IPI00027422.1Isoform Beta-4C of Integrin beta-4 precursorITGB4cell-matrix adhesion; integrin-mediated signaling pathwayup-regulation
    IPI00018219.1Transforming growth factor-beta-induced protein ig-h3 precursorTGFBIcell adhesion; negative regulation of cell adhesionup-regulation
    IPI00024095.3Annexin A3ANXA3cell motion; signal transductionup-regulation
    IPI00028091.3Actin-like protein 3ACTR3cell motion; actin filament polymerizationup-regulation
    IPI00218918.5Annexin A1ANXA1cell motion; lipid metabolic process; anti-apoptosisup-regulation
    IPI00219468.4Isoform IIa of Profilin-2PFN2actin cytoskeleton organizationup-regulation
    IPI00032313.1Protein S100-A4S100A4epithelial to mesenchymal transitiondown-regulation
  • a Functional classification of the dyesregulated proteins as revealed by annotation in the GO biological process categories.