Table I The ranking of drug targets with Regulation and Specificity calculations in attached and detached cells, as well as combined ranking. The combined rankings were generated by summing up the individual rankings and ranking the sum
DrugKnown targetsRegulationSpecificityRegulation + Specificity
La combinedDa combinedL & D combinedL combinedD combinedL & D combinedL combinedD combinedL & D combined
5-FUTYMS726296352211
MTXDHFR1162111121
PCTLTUBB2A197711113171915163
TUBB827037359416117295
TUBB4B909720530414756
TUBB2033126411493132388
TUBA1B1165416421954217539
TUBA1A13246293176437811
TUBA1C23230713051123274411022
TUBB35852121095081501814625
  • a L = living cells; D = detached or dying cells.