Table I Comparison of the effects of ERAP2 expression on the A*29:02 and B*27:05 peptidomes
Features affected by ERAP2HLA-A*29:02HLA-B*27:05a
Peptide lengthPeptides >9-mers increased: Globally higher peptide lengthPeptides >9-mers decreased: Globally lower peptide length
N-terminal flanking residues (P-1)No effectNo effect
N-terminal residues (P1)Increased destruction of peptides with ERAP2-susceptible P1 residuesIncreased destruction of peptides with ERAP2-susceptible P1 residues
Maximal increase of peptides with hydrophobic P1 residuesMaximal increase of peptides with small P1 residues.
AffinityNo alterationLower
  • aData from (37).