Table II

Representative enzyme activities identified from mouse and human proteomes by non-directed ABPP methods using a sulfonate ester probe library

EnzymeEnzyme classProteome source
Acetyl-CoA acetyltransferaseaThiolaseMouse heart
Aldehyde dehydrogenase 1bAldehyde dehydrogenaseMouse heart, rat liver
Aldehyde dehydrogenase 7aAldehyde dehydrogenaseMouse heart
Dihydrodiol dehydrogenaseaNAD/NADP-dependent oxidoreductaseMouse heart
Enoyl-CoA hydratase, peroxisomalaEnoyl-CoA hydrataseMouse heart
Human breast cancer line
Epoxide hydrolase, cytoplasmicaEpoxide hydrolaseMouse heart
GSTO1-1aGlutathione S-transferaseHuman breast cancer line
3β-Hydroxysteroid dehydrogenase Δ5-isomerase-1c3β-Hydroxysteroid dehydrogenaseMouse testis
Platelet phosphofructokinasecPhosphofructokinaseHuman breast cancer line
Type II tissue transglutaminasecTransglutaminaseHuman breast cancer line
  • a See Ref. 52.

  • b See Ref. 51.

  • c See Ref. 56.