Table II Selected putative substrates of SUMO-1 and SUMO-2/3 identified in two IPs that modulate both their sumoylation by SUMO1 or SUMO-2/3 and their protein expression levels upon hypoxia (increase in SUMO conjugation and protein expression is marked with + and decrease with −)
Genes namesProtein namesSUMO1 conjugation and protein expression modulation in hypoxiaSUMO2/3 conjugation and protein expression modulation in hypoxia
ALDOAFructose-bisphosphate aldolase A; Fructose-bisphosphate aldolase++
ALDOCFructose-bisphosphate aldolase C; Fructose-bisphosphate aldolase+
ANXA4Annexin A4; Annexin+
DARS; DKFZp781B 11202Aspartate–tRNA ligase, cytoplasmic+
ENO1Alpha-enolase++
GPIGlucose-6-phosphate isomerase++
LDHAl-lactate dehydrogenase A chain; l-lactate dehydrogenase++
LGALS3Galectin-3++
NUMA1Nuclear mitotic apparatus protein 1++
PFKP6-phosphofructokinase type C; 6-phosphofructokinase+
PGK1Phosphoglycerate kinase 1; Phosphoglycerate kinase++
PKM2Pyruvate kinase isozymes M1/M2; Pyruvate kinase++
PRDX2Peroxiredoxin-2+
SP100Nuclear autoantigen Sp-100++
TFRCTransferrin receptor protein 1; Transferrin receptor protein 1, serum form++
TPI1Triosephosphate isomerase++
TUBB6Tubulin beta-6 chain+
ZER1Protein zer-1 homolog+
AHCYAdenosylhomocysteinase
DDX21Nucleolar RNA helicase 2
EEF1GElongation factor 1-gamma
EEF1DElongation factor 1-delta
IDH1Isocitrate dehydrogenase [NADP] cytoplasmic
IMPDH2Inosine-5-monophosphate dehydrogenase 2
PSMD226S proteasome non-ATPase regulatory subunit 2
RPS1640S ribosomal protein S16
STRAPSerine-threonine kinase receptor-associated protein