TABLE I

Summary of C-mannosylated sequences

ProteinFunctionNumber of (C2-Man-)TrpSequenceaReference
RNase 2Host defence (?)1TWAQWF 4
Interleukin 12βCytokine receptor homologue1SWSEWA 27
Hypertrehalosemic hormoneNeuropeptide1 (?)bFTPNWGTG 29
Proteins with TSRs
    C6Complement; forms, together with C5, C7, C8α,6DHYAWTQWT 23
    C8β, and C9, the membrane attack complexLLGDFGPWS
QWGCWSSWS
    C7Complement4QWDFYAPWS 23
GWSCWSSWS
    C8αComplement4QLSNWSEWT 23
SWSCWSSWS
    C8βComplement4ELSSWSSWT 23
KWNCWSNWS
    C9Complement2RMSPWSEWS 23
    ProperdinPositive regulator of complement15RWSLWSTWA 37
GWSGWGPWE
AWATWGPWT
GWGPWGPVS
EWDSWGEWS
SWSEWSTWG
Thrombospondin-1TGF-β activation4GWSPWSEWT 20
Angiogenesis inhibitorGWSHWSPWS
GWGPWSPWD
F-spondinAxonal guidance8IYSNWSPWSFootnote 3
TMSEWITWS
LVTEWGEWD
LLSPWSEWS
ELSEWSQWS
  • a C-Mannosylated Trp residues have been indicated in bold (fully modified) or bold, italic (partially modified). For estimates of the degree of modification, see the original references.

  • b Gäde et al. (29) hypothesize that the unknown hexose is attached to N1 of the indole.