Table II

Published values of genetic contributions to quantitative variation of plasma proteins with literature sources referenced

PAI-1, plasminogen activator inhibitor-1. Two studies of insulin-like growth factor produced disparate results.

ProteinProportion genetic
Insulin-like growth factor-binding protein-1 (155)Very low
C-peptide (156)12
Factor xiia (157)38
Insulin-like growth factor I (155)38
Leptin (158)34–45
Prostate-specific antigen (159)45
Fibrinogen, factor VII, factor VIII, PAI-1, tissue plasminogen activator, factor XIII A-subunit and B-subunit, and von Willebrand factor (157)41–75
Insulin-like growth factor-binding protein-3 (155)60
von Willebrand factor (160)60
Insulin-like growth factor II V(155)66
Histidine-rich glycoprotein (161)69
Gc (group-specific component) (162)70
Immunoglobulin E (163)78
Factor XIII activity (157)82
Insulin-like growth factor I (156)77–93
Plasminogen activator inhibitor type 1 antigen (164)87
Lipoprotein(a) (165)93–98