Table V The summary of significantly enriched biology processes for proteins correlated with morphological features based on proteomic data
Morphology feature typeCorrelation typeMorphology featureSignificantly enriched biological process
AreaPositive correlationSmall_Nucleus_AreaCell cycle, Metabolic
Large_Nucleus_AreaMetabolic
Negative correlationSmall_Nucleus_AreaMetabolic
Large_Nucleus_AreaImmune
RatioPositive correlationSmall_Aspect_RatioImmune, Metabolic
Large_Aspect_RatioECM
Negative correlationSmall_Aspect_RatioECM
Large_Aspect_RatioMetabolic
Major_axisPositive correlationSmall_Major_AxisCell cycle, Metabolic
Large_Major_AxisECM
Negative correlationSmall_Major_AxisMetabolic
Large_Major_AxisMetabolic
Minor_axisPositive correlationSmall_Minor_AxisECM
Large_Minor_AxisMetabolic
Negative correlationSmall_Minor_AxisMetabolic
Large_Minor_AxisTME,Immune
Max_distancePositive correlationSmall_Max_DistanceImmune, Metabolic
Large_Max_DistanceECM
Negative correlationSmall_Max_DistanceECM
Large_Max_DistanceImmune, Metabolic
Min_distancePositive correlationSmall_Min_DistanceImmune, Metabolic
Large_Min_DistanceECM
Negative correlationSmall_Min_DistanceTME, Metabolic
Large_Min_DistanceImmune, Metabolic
Mean_distancePositive correlationSmall_Mean_DistanceImmune, Metabolic
Large_Mean_DistanceECM
Negative correlationSmall_Mean_DistanceECM
Large_Mean_DistanceImmune, Metabolic
  • Note: ECM related biology processes includes: extracellular matrix (ECM), cell adhesion, cell migration, and vascular system GO functions; Metabolic related biology process mostly include: Mitochondrial Ribosomal proteins (MRPs) and mRNA processing related GO functions.