Table II

Comparison of the four amino acids substituted in different osteogenesis imperfecta-associated peptides

The structural parameters for each of the peptides averaged by mutant amino acid identity identify valine as the most perturbing and alanine as the least perturbing. See text for discussion. WT, wild type.

No. of sequencesr.m.s.d.r.m.s.d.WTH-bondsH-bonds WTH-bond differenceSolvent H-bondsSolvent H-bonds WT
Ala41.170.7716.314.3−1.54.82.8
(0.21)(0.16)(0.5)(0.5)(0.7)(3.3)(2.6)
Val71.560.9315.112.0−3.15.42.6
(0.32)(0.32)(1.8)(0.6)(1.9)(3.0)(1.9)
Ser241.250.7515.914.8−1.13.02.7
(0.21)(0.14)(1.2)(1.8)(2.2)(2.3)(2.1)
Cys241.390.8115.814.0−1.72.82.2
(0.33)(0.25)(0.7)(1.4)(1.6)(2.5)(1.6)