Table IV

Comparison of mutants associated with the four forms of osteogenesis imperfecta

Structural parameters for each of the four types of osteogenesis imperfecta-associated peptides. Type II is lethal, while Types I, III, and IV are non-lethal. See text for discussion. WT, wild type.

No. of sequencesr.m.s.d.r.m.s.d. WTH-bondsH-bonds WTH-bonds differenceSolvent H-bondsSolvent H-bonds WT
I61.390.8314.315.8−1.53.01.5
(0.25)(0.24)(2.2)(1.5)(2.6)(3.7)(1.6)
II211.380.7713.615.7−2.03.92.3
(0.31)(0.20)(1.3)(1.0)(1.6)(3.0)(1.8)
III121.220.7814.916.3−1.42.92.6
(0.22)(0.16)(1.5)(0.8)(1.7)(2.2)(2.4)
IV101.300.8314.015.8−1.82.13.0
(0.28)(0.33)(2.5)(1.5)(2.9)(2.0)(1.4)