Table I The top 10 decreased and top 10 increased proteins showing the largest changes in AD
Gene nameProtein namelog2 of av. ratio (AD/C)ratio (AD/C)PSM countp valueAdjusted p value (FDR)Biological process
CPLX1Complexin-1−1.470.36100.000980.06Exocytosis, Neurotransmitter transport, Transport
HPRT1Hypoxanthine-guanine phosphoribosyltransferase−1.010.50140.006630.08Purine salvage pathway, Inosine monophosphate metabolic process
ATP5JATP synthase-coupling factor 6, mitochondrial−0.990.5080.004770.08Hydrogen ion transport, Ion transport, Transport
FAHFumarylacetoacetase−0.980.5150.009320.09Phenylalanine catabolism, Tyrosine catabolism
GNG3Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3−0.970.5160.000450.05G protein-coupled receptor signalling pathway
BCAS1Breast carcinoma-amplified sequence 1−0.940.52190.003240.07Myelination
GAP43Neuromodulin−0.930.532680.001810.06Regulation of growth
ORM1Alpha-1-acid glycoprotein 1−0.920.5370.000070.04Inflammatory response
CPLX2Complexin-2−0.900.54170.003430.07Exocytosis, Neurotransmitter transport, Neurogenesis
APOC3Apolipoprotein C-III−0.890.5410.002000.06Lipoprotein metabolic process, Cholesterol homeostasis
HRCSarcoplasmic reticulum histidine-rich calcium-binding protein1.302.4620.005100.08Cellular protein metabolic process, muscle contraction
JPH2Junctophilin-20.941.9210.003000.07Calcium ion homeostasis
CD44CD44 antigen0.931.91480.002220.06Cell adhesion, Inflammatory response, Extracellular matrix organization
GFAPGlial fibrillary acidic protein0.921.8924450.003040.07Astrocyte development
SPARCSPARC0.841.7960.001480.06Extracellular response to growth factor stimulus, Extracellular matrix organization, Response to calcium ion, Regulation of synapse organization
HSPB6Heat shock protein beta 60.821.7650.005310.08Chaperone-mediated protein folding
FAM184AProtein FAM184A0.761.69280.004900.08
ITGA3Integrin alpha 30.731.6650.000100.04Extracellular matrix organization, Cell-matrix adhesion, Dendritic spine maintenance, Memory
COLEC12Collectin 120.731.6640.001910.06Regulation of immune response
ICAM1Intercellular adhesion molecule 10.721.65110.001230.06Cell adhesion, Regulation of immune response