Table IV

Correlation between Op18 and other gene mRNAs expressed in lung adenocarcinomas

mod, moderate differentiation; BD, bronchial derived; BA, bronchioloalveolar; r, Spearman correlation coefficient between Op18 and other genes.

p value P vs. WamRNA level -fold P/Wr all tumor n = 86r BD n = 66r BA n = 20r poor n = 20r mod n = 42r well n = 23Gene nameFunctions
0.0007 1.74 0.539 0.70 0.62 0.76 0.55 0.64 TUBB Tubulin-cytoskeleton-associated
0.0001 3.37 0.530 0.61 0.63 0.64 0.49 0.63 CDC20 Cell cycle control, mitotic spindle checkpoint
0.0001 3.58 0.437 0.49 0.58 0.42 0.39 0.51 TYMS Nucleotide metabolism
0.0046 1.41 0.474 0.51 0.54 0.51 0.35 0.53 SNRPD2 RNA processing, mRNA splicing
0.0187 1.64 0.402 0.47 0.61 0.53 0.30 0.62 CDC25C Cell cycle control, protein tyrosine phosphatase
0.0037 1.47 0.422 0.45 0.52 0.62 0.29 0.50 CHAF1A DNA replication-dependent nucleosome assembly
0.0002 2.24 0.467 0.49 0.62 0.55 0.26 0.62 FEN1 DNA repair enzyme
0.0005 1.69 0.483 0.47 0.46 0.64 0.24 0.41 HDAC2 Transcription factor
0.0054 1.47 0.384 0.54 0.62 0.80 0.22 0.49 NASP DNA packaging
0.0049 1.94 0.479 0.51 0.82 0.71 0.22 0.80 LMNB1 Mitotic S-specific transcription, structural protein
0.0001 2.92 0.458 0.42 0.86 0.52 0.18 0.83 TOP2A DNA synthesis
0.0000 2.31 0.423 0.46 0.75 0.59 0.10 0.73 MCM4 DNA synthesis
0.0002 2.68 0.471 0.47 0.45 0.50 0.250.39 KNSL6 Cell proliferation, mitosis
0.0003 2.39 0.518 0.47 0.42 0.42 0.42 0.34 PCNA Cell proliferation, cell cycle control, DNA replication
0.0009 2.48 0.511 0.53 0.66 0.37 0.55 0.67 MYBL2 Transcription factor, cell cycle control
0.0026 2.10 0.686 0.48 0.60 0.30 0.54 0.62 MCM2 DNA synthesis
0.0049 1.84 0.486 0.45 0.51 0.31 0.43 0.53 NEK2 Protein kinase, cell cycle control
0.0070 1.92 0.568 0.47 0.54 0.31 0.43 0.54 CENPF Mitosis
0.0323 1.51 0.508 0.42 0.82 0.31 0.39 0.74 MCM3 DNA synthesis
0.0001 9.63 0.522 0.42 0.58 0.32 0.31 0.55 FOXM1 Cell proliferation, transcription factor
0.0070 4.10 0.549 0.32 0.76 0.24 0.31 0.76 UBCH10 Cell proliferation
0.0001 60.17 0.343 0.43 0.48 0.37 0.30 0.49 TROAP Cell adhesion
0.0016 2.04 0.571 0.43 0.66 0.380.29 0.68 TTK Cell proliferation, protein tyrosine kinase
0.0238 2.12 0.374 0.41 0.67 0.390.29 0.66 CDKN2A Cell cycle control, cyclin-dependent protein kinase inhibitor
0.0002 1.67 0.409 0.40 0.58 0.230.29 0.58 PSMB5 Protein degradation
0.0381 1.38 0.450 0.30 0.55 0.320.20 0.52 PTPN11 Protein phosphatase
0.0014 4.00 0.528 0.32 0.75 0.240.18 0.75 CDKN3 Cell cycle control, protein phosphatase
0.0072 1.58 0.451 0.50 0.39 0.55 0.33 0.41 KNSL1 Mitosis, mitotic spindle assembly
0.0101 1.35 0.598 0.59 0.36 0.55 0.49 0.38 LMNB2 Mitotic S-specific transcription, structural protein
0.0005 2.05 0.490 0.56 0.29 0.50 0.48 0.33 CCNA2 Cell cycle control, regulation of CDK activity
0.0238 1.44 0.342 0.45 0.32 0.52 0.220.31 E2F5 Cell proliferation, transcription factor
0.0000 2.86 0.456 0.49 0.27 0.44 0.36 0.30 CENPA DNA-binding protein
0.0018 1.35 0.462 0.50 0.27 0.49 0.36 0.28 PSMB2 Protein degradation
0.0001 1.96 0.546 0.49 0.32 0.67 0.270.27 CSE1L Cell proliferation, apoptosis
0.0139 2.34 0.426 0.47 0.27 0.63 0.190.26 RANBP1 Signal transduction
0.0010 1.32 0.516 0.57 0.27 0.58 0.48 0.25 CDK2 Protein kinase, cell proliferation, cell cycle control
0.0490 1.29 0.353 0.45 0.28 0.68 0.120.24 CKAP1 Tubulin-cytoskeleton-associated
0.0006 1.39 0.495 0.60 0.22 0.46 0.60 0.23 PSMD2 Protein degradation
0.0271 1.31 0.403 0.44 0.18 0.48 0.32 0.16 CCNF Cell cycle control, regulation of CDK activity
0.0004 2.13 0.446 0.38 0.12 0.48 0.220.11 MEST Central nervous system development
0.0005 1.55 0.454 0.55 −0.07 0.46 0.63 −0.04 NSEP1 Transcription factor
  • a p value between poor (P) versus well (W) differentiated tumor. Bold values indicate significant correlation, p < 0.05. False discovery rate = 9.5%.