Table I

Criteria for evaluation of prognostic factors (modified from Ref. 5)

1.Biological hypothesis
2.Simple, standardized, and reproducible determination method
3.Biostatistical planning of data analysis
4.Correlation to established factors
5.Optimized cut-off values for distinction between low- and high-risk group
6.Univariate and multivariate analysis (independence of factors/weighing)
7.Validation (different patient collective/different research group)
8.Clinical study, impact on therapy
9.Transfer into clinical practice