Table II

Description of protein states

AttributesDescription
Post-translational modificationCarbohydrate modificationsGlycation/deglycation
N-Glycosylation, O-glycosylation/deglycosylation
Lipid modificationsFarnesylation/defarnesylation
Geranylation/degeranylation
Myristoylation/demyristoylation
Palmitoylation/depalmitoylation
Prenylation/deprenylation
Stearoylation/destearoylation
Oxidation/reduction of cysteineCysteine-cysteine disulfide/disulfide-cysteine
Cysteine-cysteine sulfenic acid/cysteine sulfenic acid-cysteine
Cysteine-cysteine sulfinic acid/cysteine sulfinic acid-cysteine
Cysteine-cysteine sulfonic acid/cysteine sulfonic acide-cysteine
Cysteine-cysteine sulphenyl-amide/cysteine sulphenyl-amide-cysteine
Oxidation/reduction of selenocysteineSelenocysteine-selenocysteine diselenide/selenocysteine diselenide-selenocysteine
Selenocysteine-selenocysteine selenenate/selenocysteine selenenate-selenocysteine
Selenocysteine-selenocysteine selenenylsulfide/selenocysteine selenenylsulfide-selenocysteine
Selenocysteine-selenocysteine seleninate/selenocysteine seleninate-selenocysteine
Other oxidation or reductionCarbonylation/decarbonylation
S-Glutathiolation/deglutathiolation
Hydroxylation/dehydroxylation
Iron-sulfur oxidation/iron-sulfur reduction
Methionine sulfoxide/Methionine sulfoxide-methionine
S-Nitrosylation
Phosphorylation or dephosphorylationPhosphorylation/dephosphorylation
Proteolytic modificationsNeddylation/deneddylation
Sumoylation/desumoylation
Ubiquitination/deubiquitination
Other modifications5′-Adenosylation
Acetylation/deacetylation
ADP-ribosylation
Amidation/deamidation
Biotinylation
Carboxylation/decarboxylation
Crosslinking
Formylation/deformylation
Lipoylation
Methylation/demethylation
Nitration/denitration
Sulfation/desulfation
TruncationN-terminal, C-terminal, cleavage site
LigandADP, ATP, Ca2+, cAMP, cGMP, DAG, GDP, glucose, GTP, H2O2, heme, NADP, NADPH, NO, O2, PIP, PIP2, PIP3
Cell lineB cell, endothelial cell, epithelial cell, smooth muscle cell
Subcellular localizationCytosol, endoplasmic reticulum, endosome, extracellular region, Golgi apparatus, membrane, mitochondrion, nucleus, outer mitochondrial membrane, perinuclear region, peroxisome, plasma membrane, ribosome
ActivityActive, inactive, unknown